Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T63083 Target Info
Target Name DNA repair protein RAD51 homolog 1 (RAD51)
Synonyms hRAD51; RECA; RAD51A; RAD51 homolog A; HsRAD51
Target Type Clinical trial Target
Gene Name RAD51
UniProt ID
RAD51_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Bloom syndrome protein (BLM) Interacting Protein Interacting Protein Info
UniProt ID
BLM_HUMAN 
Synonyms BS; RECQ2; RECQL2; RECQL3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Yeast two hybrid [1]
Interacting Protein Name Transcriptional regulator ATRX (ATRX) Interacting Protein Interacting Protein Info
UniProt ID
ATRX_HUMAN 
Synonyms ATR2; JMS; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF.HX
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Reconstituted Complex [7]
Interacting Protein Name DNA repair protein RAD52 homolog (RAD52) Interacting Protein Interacting Protein Info
UniProt ID
RAD52_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
Kinases [+] 1 Kinases +
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [10]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [2]
5 Co-purification [11]
6 Reconstituted Complex [12]
Other proteins [+] 5 Other proteins +
Interacting Target Name Breast cancer type 2 susceptibility protein (BRCA2) Literature-reported Target Interacting Protein Info
UniProt ID
BRCA2_HUMAN 
Synonyms Fanconi anemia group D1 protein; FANCD1; FACD
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [14]
4 Affinity Capture-Western [15]
5 Affinity Capture-Western [16]
6 Affinity Capture-Western [17]
7 Co-localization [18]
8 Co-purification [11]
9 Protein-peptide [19]
10 Reconstituted Complex [14]
11 Yeast two hybrid [20]
12 Yeast two hybrid [15]
13 Yeast two hybrid [21]
Interacting Protein Name Microcephalin (MCPH1) Interacting Protein Interacting Protein Info
UniProt ID
MCPH1_HUMAN 
Synonyms BRIT1; MCT
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Co-localization [23]
3 Co-localization [22]
Interacting Protein Name Partner and localizer of BRCA2 (PALB2) Interacting Protein Interacting Protein Info
UniProt ID
PALB2_HUMAN 
Synonyms FANCN; PNCA3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Co-localization [24]
3 Reconstituted Complex [14]
Interacting Protein Name Meiotic recombination protein DMC1/LIM15 homolog (DMC1) Interacting Protein Interacting Protein Info
UniProt ID
DMC1_HUMAN 
Synonyms DMC1H; LIM15; dJ199H16.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [21]
2 Yeast two hybrid [25]
Interacting Protein Name Replication factor A protein 1 (RPA1) Interacting Protein Interacting Protein Info
UniProt ID
RFA1_HUMAN 
Synonyms HSSB; MST075; REPA1; RF.A; RP.A; RPA70
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [26]
2 Yeast two hybrid [27]
References  Top
REF 1 Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J Biol Chem. 2001 Jun 1;276(22):19375-81.
REF 2 The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. Oncogene. 2004 May 6;23(21):3749-56.
REF 3 BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54. J Cell Sci. 2009 Sep 1;122(Pt 17):3093-103.
REF 4 Homologous DNA pairing by human recombination factors Rad51 and Rad54. J Biol Chem. 2002 Nov 8;277(45):42790-4.
REF 5 Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997 Jan 24;88(2):265-75.
REF 6 Elevated estrogen receptor- in VHL-deficient condition induces microtubule organizing center amplification via disruption of BRCA1/Rad51 interaction. Neoplasia. 2014 Dec;16(12):1070-81.
REF 7 BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. Nature. 2017 Oct 19;550(7676):360-365.
REF 8 Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem. 1999 Apr 30;274(18):12748-52.
REF 9 Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci. 2006 Dec 15;119(Pt 24):5137-46.
REF 10 Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia. Blood. 2011 Jul 28;118(4):1062-8.
REF 11 Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003 Nov;12(5):1087-99.
REF 12 p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J. 1996 Apr 15;15(8):1992-2002.
REF 13 Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Mol Cell. 2015 Jul 16;59(2):176-87.
REF 14 Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. Mol Cell. 2016 Feb 18;61(4):535-546.
REF 15 Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control. J Biol Chem. 1999 Nov 12;274(46):32931-5.
REF 16 FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51. Nat Commun. 2015 Jan 14;6:5931.
REF 17 A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination. Genes Dev. 2016 Dec 1;30(23):2581-2595.
REF 18 Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell. 2003 Oct;12(4):1029-41.
REF 19 CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature. 2005 Mar 31;434(7033):598-604.
REF 20 Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature. 1997 Apr 24;386(6627):804-10.
REF 21 Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J. 2007 Jun 20;26(12):2915-22.
REF 22 Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res. 2009 Jul 1;69(13):5531-6.
REF 23 BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet. 2010 Jan 22;6(1):e1000826.
REF 24 Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. Oncogene. 2017 Jul 20;36(29):4161-4170.
REF 25 The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51. EMBO J. 1999 Nov 15;18(22):6552-60.
REF 26 Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic comp... J Biol Chem. 2002 Aug 30;277(35):31663-72.
REF 27 Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex. J Proteome Res. 2009 May;8(5):2211-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.