Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T61227 Target Info
Target Name IP3 receptor isoform 1 (ITPR1)
Synonyms Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor; InsP3R1; Inositol 1,4,5-trisphosphate receptor type 1; IP3R 1
Target Type Literature-reported Target
Gene Name ITPR1
Biochemical Class Ryanodine-inositol triphosphate calcium channel
UniProt ID
ITPR1_HUMAN 
Target Interacting Proteins  Top
Isomerases [+] 1 Isomerases +
Interacting Target Name FK506-binding protein 1A (FKBP1A) Successful Target Interacting Protein Info
UniProt ID
FKB1A_HUMAN 
Synonyms Rotamase; PPIase FKBP1A; Peptidyl-prolyl cis-trans isomerase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP-1A; FKBP-12; FKBP12; FKBP1; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [2]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Calcium-binding protein 1 (CABP1) Interacting Protein Interacting Protein Info
UniProt ID
CABP1_HUMAN 
Synonyms CALBRAIN; HCALB_BR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-fractionation [4]
3 Reconstituted Complex [3]
References  Top
REF 1 In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. J Cell Sci. 2005 Dec 1;118(Pt 23):5443-51.
REF 2 FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. J Biol Chem. 1997 Oct 31;272(44):27582-8.
REF 3 Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. EMBO J. 2004 Jan 28;23(2):312-21.
REF 4 Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7711-6.

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