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| Target General Information |
Top |
| Target ID |
T60514 |
Target Info
|
| Target Name |
Platelet glycoprotein VI (GP6) |
| Synonyms |
Glycoprotein 6; GPVI |
| Target Type |
Clinical trial Target |
| Gene Name |
GP6 |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Tyrosine-protein kinase Lyn (JTK8) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p56Lyn; p53Lyn; Lck/Yes-related novel protein tyrosine kinase |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Affinity Capture-Western |
[3] |
| 4 |
Reconstituted Complex |
[1] |
| References |
Top |
| REF 1 |
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem. 2002 Jun 14;277(24):21561-6.
|
| REF 2 |
Fc Rgamma -independent signaling by the platelet collagen receptor glycoprotein VI. J Biol Chem. 2003 Apr 25;278(17):15441-8.
|
| REF 3 |
TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72.
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