Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60003 | Target Info | |||
| Target Name | Protein kinase N1 (PKN1) | ||||
| Synonyms | Serine/threonine-protein kinase N1; Serine-threonine protein kinase N; Protein-kinase C-related kinase 1; Protein kinase PKN-alpha; Protein kinase C-like PKN; Protein kinase C-like 1; Protease-activated kinase 1; PRKCL1; PRK1; PKN; PAK1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PKN1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acid anhydride hydrolases | [+] 1 Acid anhydride hydrolases | + | |||
| Interacting Target Name | Transforming protein RhoA (RHOA) | Discontinued Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transforming protein RhoA; RHO12; Rho cDNA clone 12; h12; ARHA; ARH12 | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Co-crystal Structure | [1] | |||
| 2 | Far Western | [2] | |||
| 3 | Reconstituted Complex | [3] | |||
| 4 | Reconstituted Complex | [2] | |||
| 5 | Yeast two hybrid | [4] | |||
| Intermediate filaments | [+] 1 Intermediate filaments | + | |||
| Interacting Protein Name | Vimentin (VIM) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CTRCT30; HEL113 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [5] | |||
| 2 | Yeast two hybrid | [5] | |||
| 3 | Yeast two hybrid | [6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. Mol Cell. 1999 Nov;4(5):793-803. | ||||
| REF 2 | Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif. J Biol Chem. 1998 Jan 30;273(5):2698-705. | ||||
| REF 3 | Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. J Biol Chem. 1998 Apr 10;273(15):8616-22. | ||||
| REF 4 | RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol. 2003 Jun;23(12):4219-29. | ||||
| REF 5 | Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN. Biochem Biophys Res Commun. 1997 May 29;234(3):621-5. | ||||
| REF 6 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
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