Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T59686 Target Info
Target Name Methyl cpg binding protein 2 (MECP2)
Synonyms MethylCpGbinding protein 2; Methyl-CpG-binding protein 2; MeCp2 protein; MeCp2; MeCp-2 protein
Target Type Clinical trial Target
Gene Name MECP2
UniProt ID
MECP2_HUMAN 
Target Interacting Proteins  Top
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Recombining binding protein suppressor of hairless (RBPJ) Literature-reported Target Interacting Protein Info
UniProt ID
SUH_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-30; RBPSUH; RBP-JK; RBPJK; RBP-J kappa; RBP-J; J kappa-recombination signal-binding protein; IGKJRB1; IGKJRB; CBF-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Paired amphipathic helix protein Sin3a (SIN3A) Interacting Protein Interacting Protein Info
UniProt ID
SIN3A_HUMAN 
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Reconstituted Complex [8]
6 Reconstituted Complex [11]
References  Top
REF 1 DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003 Oct 31;302(5646):890-3.
REF 2 Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. Oncogene. 2006 Apr 20;25(17):2477-88.
REF 3 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 4 Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death Differ. 2007 Feb;14(2):275-85.
REF 5 Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3243-E3250.
REF 6 The Ski protein family is required for MeCP2-mediated transcriptional repression. J Biol Chem. 2001 Sep 7;276(36):34115-21.
REF 7 Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet. 1998 Jun;19(2):187-91.
REF 8 Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 1998 May 28;393(6683):386-9.
REF 9 MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. J Biol Chem. 2004 Nov 5;279(45):46490-6.
REF 10 Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation. Mol Cell Biol. 2012 Jul;32(14):2894-903.
REF 11 Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res. 2000 May 15;28(10):2201-6.

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