Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T59550 Target Info
Target Name CI Man-6-P receptor (IGF2R)
Synonyms MPRI; MPR 300; M6PR; M6P/IGF2R; M6P/IGF2 receptor; Insulinlike growth factor II receptor; Insulinlike growth factor 2 receptor; Insulin-like growth factor II receptor; Insulin-like growth factor 2 receptor; IGFII receptor; IGF-II receptor; Cationindependent mannose6phosphate receptor; Cation-independent mannose-6-phosphate receptor; CIMPR; CI-MPR; CD222; 300 kDa mannose 6phosphate receptor; 300 kDa mannose 6-phosphate receptor
Target Type Clinical trial Target
Gene Name IGF2R
Biochemical Class Mannose 6-phosphate receptor
UniProt ID
MPRI_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 4 Other proteins +
Interacting Protein Name ADP-ribosylation factor-binding protein GGA3 (GGA3) Interacting Protein Interacting Protein Info
UniProt ID
GGA3_HUMAN 
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-crystal Structure [1]
6 Yeast two hybrid [5]
7 Yeast two hybrid [6]
8 Yeast two hybrid [1]
Interacting Protein Name ADP-ribosylation factor-binding protein GGA1 (GGA1) Interacting Protein Interacting Protein Info
UniProt ID
GGA1_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Yeast two hybrid [6]
Interacting Protein Name ADP-ribosylation factor-binding protein GGA2 (GGA2) Interacting Protein Interacting Protein Info
UniProt ID
GGA2_HUMAN 
Synonyms VEAR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [4]
3 Yeast two hybrid [6]
Interacting Protein Name Perilipin-3 (PLIN3) Interacting Protein Interacting Protein Info
UniProt ID
PLIN3_HUMAN 
Synonyms M6PRBP1; PP17; TIP47
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [7]
2 Reconstituted Complex [8]
3 Yeast two hybrid [7]
References  Top
REF 1 Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism. Nat Struct Biol. 2002 Jul;9(7):532-6.
REF 2 Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry. 2003 Oct 28;42(42):12174-80.
REF 3 Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8072-7.
REF 4 Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. J Biol Chem. 2001 Jul 27;276(30):28541-5.
REF 5 Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes. Mol Cell Biol. 2005 Sep;25(18):7988-8000.
REF 6 Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature. 2002 Feb 21;415(6874):933-7.
REF 7 TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell. 1998 May 1;93(3):433-43.
REF 8 Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9047-51.

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