Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T59136 Target Info
Target Name PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1)
Synonyms TRF1-interacting protein 1; Protein 67-11-3; Pin2-interacting protein X1; Liver-related putative tumor suppressor; LPTS; LPTL
Target Type Literature-reported Target
Gene Name PINX1
UniProt ID
PINX1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (DHX15) Interacting Protein Interacting Protein Info
UniProt ID
DHX15_HUMAN 
Synonyms DBP1; DDX15; HRH2; PRP43; PRPF43; PrPp43p
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [2]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Telomeric repeat-binding factor 1 (TERF1) Literature-reported Target Interacting Protein Info
UniProt ID
TERF1_HUMAN 
Synonyms TTAGGG repeat-binding factor 1; TRF1; TRF; TRBF1; Telomeric protein Pin2/TRF1; PIN2; NIMA-interacting protein 2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Reconstituted Complex [5]
6 Yeast two hybrid [6]
References  Top
REF 1 The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis. Nucleic Acids Res. 2014 Jun;42(11):7330-45.
REF 2 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 5 The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell. 2001 Nov 2;107(3):347-59.
REF 6 Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1. J Biol Chem. 2009 Mar 27;284(13):8557-66.

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