Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T58924 Target Info
Target Name SRSF protein kinase 2 (SRPK2)
Synonyms Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2; SFRS protein kinase 2
Target Type Literature-reported Target
Gene Name SRPK2
Biochemical Class Kinase
UniProt ID
SRPK2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name Nucleolar RNA helicase 2 (DDX21) Interacting Protein Interacting Protein Info
UniProt ID
DDX21_HUMAN 
Synonyms GUA; GURDB; RH.II/GU; RH.II/GuA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Biochemical Activity [2]
4 Fluorescence Resonance Energy Transfer [1]
Interacting Protein Name Probable ATP-dependent RNA helicase DDX46 (DDX46) Interacting Protein Interacting Protein Info
UniProt ID
DDX46_HUMAN 
Synonyms PRPF5; Prp5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
3 Yeast two hybrid [3]
Interacting Protein Name ATP-dependent RNA helicase DDX50 (DDX50) Interacting Protein Interacting Protein Info
UniProt ID
DDX50_HUMAN 
Synonyms GU2; GUB; RH.II/GuB; mcdrh
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name Spliceosome RNA helicase DDX39B (DDX39B) Interacting Protein Interacting Protein Info
UniProt ID
DX39B_HUMAN 
Synonyms BAT1; D6S81E; UAP56
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Hydrolysis-driven transporters [+] 4 Hydrolysis-driven transporters +
Interacting Protein Name Serine/arginine repetitive matrix protein 1 (SRRM1) Interacting Protein Interacting Protein Info
UniProt ID
SRRM1_HUMAN 
Synonyms 160.KD; POP101; SRM160
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
3 Fluorescence Resonance Energy Transfer [1]
Interacting Protein Name Apoptotic chromatin condensation inducer in the nucleus (ACIN1) Interacting Protein Interacting Protein Info
UniProt ID
ACINU_HUMAN 
Synonyms ACINUS; ACN; fSAP152
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [4]
3 Yeast two hybrid [3]
Interacting Protein Name Pinin (PNN) Interacting Protein Interacting Protein Info
UniProt ID
PININ_HUMAN 
Synonyms DRS; DRSP; SDK3; memA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name Protein SON (SON) Interacting Protein Interacting Protein Info
UniProt ID
SON_HUMAN 
Synonyms BASS1; C21orf50; DBP.5; NREBP; SON3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Kinases [+] 2 Kinases +
Interacting Protein Name Cyclin-dependent kinase 13 (CDK13) Interacting Protein Interacting Protein Info
UniProt ID
CDK13_HUMAN 
Synonyms CDC2L; CDC2L5; CHED; hCDK13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name Serine/threonine-protein kinase PRP4 homolog (PRPF4B) Interacting Protein Interacting Protein Info
UniProt ID
PRP4B_HUMAN 
Synonyms PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Protein Name Tight junction protein ZO-2 (TJP2) Interacting Protein Interacting Protein Info
UniProt ID
ZO2_HUMAN 
Synonyms C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name Proliferation-associated nucleolar protein p120 (NOP2) Interacting Protein Interacting Protein Info
UniProt ID
NOP2_HUMAN 
Synonyms Proliferation-associated nucleolar protein p120; Proliferating-cell nucleolar antigen p120; Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Nucleolar protein 2 homolog; Nucleolar protein 1; NSUN1; NOL1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [5]
Splicing factors [+] 10 Splicing factors +
Interacting Protein Name RNA-binding protein 39 (RBM39) Interacting Protein Interacting Protein Info
UniProt ID
RBM39_HUMAN 
Synonyms CAPER; CAPERalpha; FSAP59; HCC1; RNPC2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Biochemical Activity [2]
4 Biochemical Activity [1]
5 Fluorescence Resonance Energy Transfer [1]
6 Yeast two hybrid [3]
7 Yeast two hybrid [6]
Interacting Protein Name Serine/arginine-rich splicing factor 1 (SRSF1) Interacting Protein Interacting Protein Info
UniProt ID
SRSF1_HUMAN 
Synonyms ASF; SF2; SF2p33; SFRS1; SRp30a
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
3 Biochemical Activity [1]
4 Biochemical Activity [7]
5 Biochemical Activity [9]
Interacting Protein Name Splicing factor U2AF 65 kDa subunit (U2AF2) Interacting Protein Interacting Protein Info
UniProt ID
U2AF2_HUMAN 
Synonyms U2AF65
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Biochemical Activity [8]
4 Fluorescence Resonance Energy Transfer [1]
5 Yeast two hybrid [10]
Interacting Protein Name Splicing factor U2AF 35 kDa subunit (U2AF1) Interacting Protein Interacting Protein Info
UniProt ID
U2AF1_HUMAN 
Synonyms FP793; RN; RNU2AF1; U2AF35; U2AFBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Fluorescence Resonance Energy Transfer [1]
3 Yeast two hybrid [3]
4 Yeast two hybrid [6]
Interacting Protein Name Serine/arginine-rich splicing factor 2 (SRSF2) Interacting Protein Interacting Protein Info
UniProt ID
SRSF2_HUMAN 
Synonyms PR264; SC.35; SC35; SFRS2; SFRS2A; SRp30b
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [8]
3 Biochemical Activity [4]
Interacting Protein Name Serine/arginine-rich splicing factor 3 (SRSF3) Interacting Protein Interacting Protein Info
UniProt ID
SRSF3_HUMAN 
Synonyms SFRS3; SRp20
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [8]
2 Biochemical Activity [1]
3 Biochemical Activity [2]
Interacting Protein Name Serine/arginine-rich splicing factor 6 (SRSF6) Interacting Protein Interacting Protein Info
UniProt ID
SRSF6_HUMAN 
Synonyms B52; HEL.S.91; SFRS6; SRP55
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [8]
3 Biochemical Activity [2]
Interacting Protein Name CLK4-associating serine/arginine rich protein (CLASRP) Interacting Protein Interacting Protein Info
UniProt ID
CLASR_HUMAN 
Synonyms CLASP; SFRS16; SWAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name Serine/arginine-rich splicing factor 5 (SRSF5) Interacting Protein Interacting Protein Info
UniProt ID
SRSF5_HUMAN 
Synonyms HRS; SFRS5; SRP40
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [8]
2 Biochemical Activity [1]
Interacting Protein Name Probable RNA-binding protein 23 (RBM23) Interacting Protein Interacting Protein Info
UniProt ID
RBM23_HUMAN 
Synonyms CAPERbeta; RNPC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [1]
2 Yeast two hybrid [3]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Bcl-2-associated transcription factor 1 (BCLAF1) Interacting Protein Interacting Protein Info
UniProt ID
BCLF1_HUMAN 
Synonyms BTF; bK211L9.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Other proteins [+] 13 Other proteins +
Interacting Protein Name U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) Interacting Protein Interacting Protein Info
UniProt ID
RU17_HUMAN 
Synonyms RNPU1Z; RPU1; SNRP70; Snp1; U1.70K; U170K; U1AP; U1RNP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [8]
3 Biochemical Activity [1]
4 Biochemical Activity [2]
5 Yeast two hybrid [3]
Interacting Protein Name Putative RNA-binding protein Luc7-like 1 (LUC7L) Interacting Protein Interacting Protein Info
UniProt ID
LUC7L_HUMAN 
Synonyms LUC7.LIKE; LUC7B1; Luc7; SR+89; hLuc7B1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Biochemical Activity [2]
4 Biochemical Activity [1]
Interacting Protein Name Pre-mRNA-splicing factor 38A (PRPF38A) Interacting Protein Interacting Protein Info
UniProt ID
PR38A_HUMAN 
Synonyms Prp38
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [2]
2 Biochemical Activity [1]
3 Yeast two hybrid [3]
4 Yeast two hybrid [6]
Interacting Protein Name Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) Interacting Protein Interacting Protein Info
UniProt ID
HNRPC_HUMAN 
Synonyms C1; C2; HNRNP; HNRPC; SNRPC
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
3 Biochemical Activity [1]
Interacting Protein Name U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (SNRNP27) Interacting Protein Interacting Protein Info
UniProt ID
SNR27_HUMAN 
Synonyms 27K; RY1
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [1]
2 Yeast two hybrid [3]
3 Yeast two hybrid [6]
Interacting Protein Name Arginine and glutamate-rich protein 1 (ARGLU1) Interacting Protein Interacting Protein Info
UniProt ID
ARGL1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [1]
2 Yeast two hybrid [3]
Interacting Protein Name Death-inducer obliterator 1 (DIDO1) Interacting Protein Interacting Protein Info
UniProt ID
DIDO1_HUMAN 
Synonyms BYE1; C20orf158; DATF.1; DATF1; DIDO2; DIDO3; DIO.1; DIO1; dJ885L7.8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name Fragile X mental retardation syndrome-related protein 2 (FXR2) Interacting Protein Interacting Protein Info
UniProt ID
FXR2_HUMAN 
Synonyms FMR1L2; FXR2P
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [2]
2 Yeast two hybrid [6]
Interacting Protein Name Luc7-like protein 3 (LUC7L3) Interacting Protein Interacting Protein Info
UniProt ID
LC7L3_HUMAN 
Synonyms CRA; CREAP.1; CROP; LUC7A; OA48.18; hLuc7A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [9]
Interacting Protein Name Poly(rC)-binding protein 1 (PCBP1) Interacting Protein Interacting Protein Info
UniProt ID
PCBP1_HUMAN 
Synonyms HEL.S.85; HNRPE1; HNRPX; hnRNP.E1; hnRNP.X
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name Smad nuclear-interacting protein 1 (SNIP1) Interacting Protein Interacting Protein Info
UniProt ID
SNIP1_HUMAN 
Synonyms PMRED
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [2]
2 Yeast two hybrid [3]
Interacting Protein Name Serine/arginine repetitive matrix protein 2 (SRRM2) Interacting Protein Interacting Protein Info
UniProt ID
SRRM2_HUMAN 
Synonyms 300.KD; CWF21; Cwc21; SRL300; SRm300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (ZRSR2) Interacting Protein Interacting Protein Info
UniProt ID
U2AFM_HUMAN 
Synonyms U2AF1.RS2; U2AF1L2; U2AF1RS2; URP
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [1]
2 Yeast two hybrid [6]
References  Top
REF 1 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 2 SR protein kinases promote splicing of nonconsensus introns. Nat Struct Mol Biol. 2015 Aug;22(8):611-7.
REF 3 Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell. 2012 Feb 24;45(4):567-80.
REF 4 Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. J Biol Chem. 2009 Sep 4;284(36):24512-25.
REF 5 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 6 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 7 The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem. 1999 Apr 16;274(16):11125-31.
REF 8 SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol. 1998 Feb 23;140(4):737-50.
REF 9 Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Biochem Biophys Res Commun. 2003 Feb 7;301(2):324-9.
REF 10 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.

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