Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T58449 Target Info
Target Name Cyclin-dependent kinase 7 (CDK7)
Synonyms TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase
Target Type Clinical trial Target
Gene Name CDK7
Biochemical Class Kinase
UniProt ID
CDK7_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) Interacting Protein Interacting Protein Info
UniProt ID
ERCC3_HUMAN 
Synonyms BTF2; GTF2H; RAD25; TFIIH; XPB
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Reconstituted Complex [7]
Interacting Protein Name General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) Interacting Protein Interacting Protein Info
UniProt ID
ERCC2_HUMAN 
Synonyms COFS2; EM9; TFIIH; TTD; XPD
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [9]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [5]
5 Co-fractionation [10]
Cell cycle related proteins [+] 2 Cell cycle related proteins +
Interacting Protein Name Cyclin-H (CCNH) Interacting Protein Interacting Protein Info
UniProt ID
CCNH_HUMAN 
Synonyms CAK; CycH; p34; p37
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
4 Affinity Capture-Western [11]
5 Affinity Capture-Western [12]
6 Affinity Capture-Western [4]
7 Affinity Capture-Western [5]
8 Affinity Capture-Western [13]
9 Affinity Capture-Western [6]
10 Co-fractionation [14]
11 Co-fractionation [15]
12 Co-fractionation [16]
13 Reconstituted Complex [17]
14 Reconstituted Complex [18]
15 Yeast two hybrid [11]
Interacting Target Name Cyclin A2 (CCNA2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNA2_HUMAN 
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [20]
Kinases [+] 1 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [19]
3 Biochemical Activity [20]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Reconstituted Complex [22]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Biochemical Activity [24]
3 Biochemical Activity [25]
Other proteins [+] 4 Other proteins +
Interacting Protein Name CDK-activating kinase assembly factor MAT1 (MNAT1) Interacting Protein Interacting Protein Info
UniProt ID
MAT1_HUMAN 
Synonyms CAP35; MAT1; RNF66; TFB3
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
4 Affinity Capture-Western [26]
5 Affinity Capture-Western [13]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [27]
8 Co-fractionation [10]
9 Reconstituted Complex [17]
Interacting Protein Name General transcription factor IIH subunit 1 (GTF2H1) Interacting Protein Interacting Protein Info
UniProt ID
TF2H1_HUMAN 
Synonyms BTF2; P62; TFB1; TFIIH
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [5]
5 Reconstituted Complex [7]
Interacting Protein Name General transcription factor IIH subunit 2 (GTF2H2) Interacting Protein Interacting Protein Info
UniProt ID
TF2H2_HUMAN 
Synonyms BTF2; BTF2P44; T.BTF2P44; TFIIH; p44
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [7]
Interacting Protein Name General transcription factor IIH subunit 3 (GTF2H3) Interacting Protein Interacting Protein Info
UniProt ID
TF2H3_HUMAN 
Synonyms BTF2; P34; TFB4; TFIIH
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [7]
References  Top
REF 1 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell. 2007 Jul 20;27(2):262-74.
REF 2 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 3 Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. EMBO J. 1997 Apr 1;16(7):1628-37.
REF 4 Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor. Cancer Res. 1995 Dec 15;55(24):6058-62.
REF 5 Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6482-7.
REF 6 Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase. Mol Cell Biol. 1999 Apr;19(4):2863-71.
REF 7 The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH. Nucleic Acids Res. 2017 Oct 13;45(18):10872-10883.
REF 8 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 9 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 10 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 11 A cyclin associated with the CDK-activating kinase MO15. Nature. 1994 Sep 15;371(6494):254-7.
REF 12 The CDK inhibitor, p27Kip1, is required for IL-4 regulation of astrocyte proliferation. J Immunol. 1997 Jul 15;159(2):812-9.
REF 13 In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J. 1995 Nov 15;14(22):5608-17.
REF 14 HIV-1 Tat interacts with LIS1 protein. Retrovirology. 2005 Feb 7;2:6.
REF 15 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 16 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature. 2001 Nov 15;414(6861):322-5.
REF 17 The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 1997 Oct 15;11(20):2645-57.
REF 18 Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Mol Cell. 2015 Sep 3;59(5):794-806.
REF 19 Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol. 2006 Jan;13(1):55-62.
REF 20 Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Mol Cell Biol. 2001 Jan;21(1):88-99.
REF 21 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 22 From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. J Biol Chem. 2000 Mar 31;275(13):9308-13.
REF 23 Regulation of CAK kinase activity by p53. Oncogene. 1998 Nov 26;17(21):2733-41.
REF 24 p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol. 1997 Dec;17(12):7220-9.
REF 25 The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol Cell Biol. 1997 Oct;17(10):5923-34.
REF 26 MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation f... J Biol Chem. 2003 Mar 28;278(13):11676-85.
REF 27 Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. J Biol Chem. 2000 Jul 28;275(30):22815-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.