Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57718 | Target Info | |||
| Target Name | Melanoma-associated antigen C2 (MAGEC2) | ||||
| Synonyms | MAGEE1 antigen; MAGEE1; MAGEC2 antigen; MAGE-E1 antigen; MAGE-C2 antigen; Hepatocellular carcinomaassociated antigen 587; Hepatocellular carcinoma-associated antigen 587; HCA587; Cancer/testis antigen 10; CT10 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MAGEC2 | ||||
| Biochemical Class | Melanoma associated antigen | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Target Name | Transcription intermediary factor 1-beta (TRIM28) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tripartite motif-containing protein 28; TIF1-beta; TIF1B; RNF96; RING-type E3 ubiquitin transferase TIF1-beta; RING finger protein 96; Nuclear corepressor KAP-1; KRIP-1; KRAB-interacting protein 1; KRAB-associated protein 1; KAP-1; KAP1; E3 SUMO-protein ligase TRIM28 | ||||
| Evidence Score (E-score) | 7 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-MS | [2] | |||
| 3 | Affinity Capture-MS | [3] | |||
| 4 | Affinity Capture-Western | [4] | |||
| 5 | Reconstituted Complex | [1] | |||
| 6 | Reconstituted Complex | [5] | |||
| 7 | Yeast two hybrid | [4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74. | ||||
| REF 2 | Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2014 Jul 11;449(4):386-91. | ||||
| REF 3 | The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling. Oncogene. 2017 Mar;36(11):1476-1486. | ||||
| REF 4 | Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1. Arch Biochem Biophys. 2011 Apr 15;508(2):217-21. | ||||
| REF 5 | MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. J Invest Dermatol. 2013 Mar;133(3):759-767. | ||||
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