Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T57059 Target Info
Target Name E2F transcription factor 1 (E2F1)
Synonyms pRB-binding protein E2F-1; Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP3; RBBP-3; RBAP-1; PBR3; E2F-1
Target Type Clinical trial Target
Gene Name E2F1
UniProt ID
E2F1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Co-localization [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Interacting Protein Info
UniProt ID
SIR1_HUMAN 
Synonyms SIR2-like protein 1; SIR2L1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; hSIR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
Cell division cycle proteins [+] 2 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-fractionation [7]
3 Reconstituted Complex [8]
Interacting Protein Name Retinoblastoma-like protein 1 (RBL1) Interacting Protein Interacting Protein Info
UniProt ID
RBL1_HUMAN 
Synonyms CP107; PRB1; p107
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Kinases [+] 1 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [12]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [13]
2 Yeast two hybrid [14]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [15]
Interacting Protein Name TATA-box-binding protein (TBP) Interacting Protein Interacting Protein Info
UniProt ID
TBP_HUMAN 
Synonyms GTF2D; GTF2D1; HDL4; SCA17; TFIID
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [17]
Interacting Protein Name Transcription factor Dp-1 (TFDP1) Interacting Protein Interacting Protein Info
UniProt ID
TFDP1_HUMAN 
Synonyms DP1; DRTF1; Dp.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [19]
Interacting Protein Name Transcription factor Dp-2 (TFDP2) Interacting Protein Interacting Protein Info
UniProt ID
TFDP2_HUMAN 
Synonyms DP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [19]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [21]
Other proteins [+] 6 Other proteins +
Interacting Target Name Prohibitin (PHB) Literature-reported Target Interacting Protein Info
UniProt ID
PHB_HUMAN 
Synonyms PHB1; HEL-215; HEL-S-54e
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Co-localization [23]
3 Reconstituted Complex [22]
Interacting Protein Name Necdin (NDN) Interacting Protein Interacting Protein Info
UniProt ID
NECD_HUMAN 
Synonyms HsT16328; PWCR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Reconstituted Complex [25]
3 Yeast two hybrid [25]
Interacting Target Name Bromodomain-containing protein 2 (BRD2) Clinical trial Target Interacting Protein Info
UniProt ID
BRD2_HUMAN 
Synonyms RING3; Really interesting new gene 3 protein; O27.1.1; KIAA9001
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Co-purification [26]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [27]
Interacting Protein Name General transcription factor IIH subunit 1 (GTF2H1) Interacting Protein Interacting Protein Info
UniProt ID
TF2H1_HUMAN 
Synonyms BTF2; P62; TFB1; TFIIH
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Reconstituted Complex [29]
Interacting Protein Name DNA topoisomerase 2-binding protein 1 (TOPBP1) Interacting Protein Interacting Protein Info
UniProt ID
TOPB1_HUMAN 
Synonyms TOP2BP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Yeast two hybrid [31]
References  Top
REF 1 DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues. Cell Death Dis. 2017 May 25;8(5):e2816.
REF 2 ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol. 2004 Jun;24(12):5157-71.
REF 3 Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol Cell Biol. 2006 May;26(10):3810-23.
REF 4 hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage. Mol Cell Biol. 2009 Apr;29(8):1989-98.
REF 5 Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol. 2006 Sep;8(9):1025-31.
REF 6 ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 2011 Nov 11;147(4):773-88.
REF 7 Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007 Apr 18;26(8):2083-93.
REF 8 E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6914-8.
REF 9 E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2850-5.
REF 10 Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J Virol. 1993 Dec;67(12):7641-7.
REF 11 Specific regulation of E2F family members by cyclin-dependent kinases. Mol Cell Biol. 1997 Jul;17(7):3867-75.
REF 12 Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases. Cancer Res. 2001 Feb 15;61(4):1347-53.
REF 13 The CBP co-activator stimulates E2F1/DP1 activity. Nucleic Acids Res. 1996 Nov 1;24(21):4139-45.
REF 14 Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. Mol Cell Biol. 2003 Jun;23(11):3707-20.
REF 15 Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol Cell Biol. 1996 Apr;16(4):1668-75.
REF 16 Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation. Mol Cell Biochem. 2007 Jan;294(1-2):45-54.
REF 17 The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res. 1993 Nov 11;21(22):4998-5004.
REF 18 A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. Oncogene. 1998 Aug 20;17(7):853-65.
REF 19 In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995 May;15(5):2536-46.
REF 20 Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene. 2005 Nov 3;24(48):7238-47.
REF 21 ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1. FEBS J. 2008 Oct;275(19):4875-86.
REF 22 A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem Biophys Res Commun. 2003 Dec 12;312(2):459-66.
REF 23 Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J Biol Chem. 2003 Nov 28;278(48):47853-61.
REF 24 Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J Biol Chem. 1998 Jan 9;273(2):720-8.
REF 25 Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J Biol Chem. 2004 Jan 16;279(3):1703-12.
REF 26 RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ. 2000 Aug;11(8):417-24.
REF 27 Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat Cell Biol. 1999 May;1(1):14-9.
REF 28 Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase. EMBO J. 1999 Aug 2;18(15):4280-91.
REF 29 Modular organization of the E2F1 activation domain and its interaction with general transcription factors TBP and TFIIH. Oncogene. 1997 Nov 27;15(22):2643-58.
REF 30 E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair. J Biol Chem. 2010 Jun 18;285(25):19308-15.
REF 31 Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol. 2003 May;23(9):3287-304.

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