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| Target General Information |
Top |
| Target ID |
T55689 |
Target Info
|
| Target Name |
Hormone sensitive lipase (LIPE) |
| Synonyms |
Hormone-sensitive lipase; HSL |
| Target Type |
Successful Target |
| Gene Name |
LIPE |
| Biochemical Class |
Carboxylic ester hydrolase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Target Name |
Lipid droplet-associated protein (PLIN1) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
PLIN1; PERI; Lipid droplet-associated protein |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Fluorescence Resonance Energy Transfer |
[2] |
| 3 |
Fluorescence Resonance Energy Transfer |
[1] |
| 4 |
Protein-Fragment Complementation Assay |
[2] |
| References |
Top |
| REF 1 |
Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J Biol Chem. 2009 Nov 13;284(46):32116-25.
|
| REF 2 |
Analysis of lipolytic protein trafficking and interactions in adipocytes. J Biol Chem. 2007 Feb 23;282(8):5726-35.
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