Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T54973 Target Info
Target Name Proteasome beta-1 (PS beta-1)
Synonyms Proteasome subunit beta type-6; Proteasome subunit Y; Proteasome delta chain; Multicatalytic endopeptidase complex delta chain; Macropain delta chain; LMPY
Target Type Patented-recorded Target
Gene Name PSMB6
Biochemical Class Peptidase
UniProt ID
PSB6_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Renal carcinoma antigen NY-REN-54 (UBE3A) Literature-reported Target Interacting Protein Info
UniProt ID
UBE3A_HUMAN 
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Peptidases [+] 5 Peptidases +
Interacting Target Name Proteasome beta-2 (PS beta-2) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB7_HUMAN 
Synonyms Proteasome subunit Z; Proteasome subunit beta type-7; Multicatalytic endopeptidase complex chain Z; Macropain chain Z
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Co-fractionation [3]
3 Yeast two hybrid [4]
4 Yeast two hybrid [5]
Interacting Protein Name Proteasome subunit beta type-3 (PSMB3) Interacting Protein Interacting Protein Info
UniProt ID
PSB3_HUMAN 
Synonyms HC10.II
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [6]
2 Co-fractionation [7]
3 Yeast two hybrid [5]
Interacting Target Name Proteasome beta-5 (PS beta-5) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB5_HUMAN 
Synonyms Proteasome subunit X; Proteasome subunit MB1; Proteasome subunit beta type-5; Proteasome epsilon chain; Proteasome chain 6; Multicatalytic endopeptidase complex epsilon chain; MB1; Macropain epsilon chain; LMPX
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Co-fractionation [6]
Interacting Target Name Proteasome beta-8 (PS beta-8) Clinical trial Target Interacting Protein Info
UniProt ID
PSB8_HUMAN 
Synonyms Y2; RING10; Really interesting new gene 10 protein; PSMB5i; Proteasome subunit beta-5i; Proteasome subunit beta type-8; Proteasome component C13; Multicatalytic endopeptidase complex subunit C13; Macropain subunit C13; Low molecular mass protein 7; LMP7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Co-fractionation [3]
Interacting Target Name Ubiquitin C-terminal hydrolase UCH37 (UCHL5) Patented-recorded Target Interacting Protein Info
UniProt ID
UCHL5_HUMAN 
Synonyms UCH-L5; UCH37; Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI-70; AD-019
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Co-fractionation [7]
References  Top
REF 1 Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012 Aug;32(15):3095-106.
REF 2 Pronounced up-regulation of the PA28alpha/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation. Eur J Immunol. 2001 Nov;31(11):3271-80.
REF 3 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 4 Protein-protein interactions among human 20S proteasome subunits and proteassemblin. Biochem Biophys Res Commun. 2004 Feb 6;314(2):523-8.
REF 5 The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO Rep. 2007 Dec;8(12):1170-5.
REF 6 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 7 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 8 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.

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