Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T53890 Target Info
Target Name Gankyrin (PSMD10)
Synonyms p28(GANK); 26S proteasome regulatory subunit p28; 26S proteasome non-ATPase regulatory subunit 10
Target Type Literature-reported Target
Gene Name PSMD10
UniProt ID
PSD10_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name Proteasome 26S subunit ATPase 4 (PSMC4) Interacting Protein Interacting Protein Info
UniProt ID
PRS6B_HUMAN 
Synonyms MIP224; RPT3; S6; TBP.7; TBP7
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Co-fractionation [4]
7 Co-purification [2]
8 Reconstituted Complex [2]
9 Yeast two hybrid [2]
10 Yeast two hybrid [5]
Interacting Protein Name Proteasome 26S subunit ATPase 5 (PSMC5) Interacting Protein Interacting Protein Info
UniProt ID
PRS8_HUMAN 
Synonyms S8; SUG.1; SUG1; TBP10; TRIP1; p45; p45/SUG
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-MS [1]
3 Co-fractionation [4]
4 Reconstituted Complex [6]
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
Interacting Protein Name Proteasome 26S subunit ATPase 2 (PSMC2) Interacting Protein Interacting Protein Info
UniProt ID
PRS7_HUMAN 
Synonyms MSS1; Nbla10058; S7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Proteasomal ATPase-associated factor 1 (PAAF1) Interacting Protein Interacting Protein Info
UniProt ID
PAAF1_HUMAN 
Synonyms PAAF; Rpn14; WDR71
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Proteasome 26S subunit non-ATPase 7 (PSMD7) Interacting Protein Interacting Protein Info
UniProt ID
PSMD7_HUMAN 
Synonyms MOV34; P40; Rpn8; S12
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
3 Co-fractionation [8]
Proteasome components [+] 7 Proteasome components +
Interacting Protein Name Proteasome 26S subunit non-ATPase 11 (PSMD11) Interacting Protein Interacting Protein Info
UniProt ID
PSD11_HUMAN 
Synonyms Rpn6; S9; p44.5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
3 Co-fractionation [8]
Interacting Protein Name Tumor necrosis factor type 1 receptor-associated protein 2 (PSMD2) Interacting Protein Interacting Protein Info
UniProt ID
PSMD2_HUMAN 
Synonyms P97; RPN1; S2; TRAP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
3 Co-fractionation [8]
Interacting Protein Name Proteasome 26S subunit non-ATPase 3 (PSMD3) Interacting Protein Interacting Protein Info
UniProt ID
PSMD3_HUMAN 
Synonyms P58; RPN3; S3; TSTA2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
3 Co-fractionation [8]
Interacting Protein Name Proteasome 26S subunit non-ATPase 12 (PSMD12) Interacting Protein Interacting Protein Info
UniProt ID
PSD12_HUMAN 
Synonyms Rpn5; p55
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [8]
Interacting Protein Name Proteasome 26S subunit non-ATPase 1 (PSMD1) Interacting Protein Interacting Protein Info
UniProt ID
PSMD1_HUMAN 
Synonyms P112; Rpn2; S1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [8]
Interacting Protein Name Proteasome 26S subunit non-ATPase 4 (PSMD4) Interacting Protein Interacting Protein Info
UniProt ID
PSMD4_HUMAN 
Synonyms AF; AF.1; ASF; MCB1; Rpn10; S5A; pUB.R5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [8]
Interacting Protein Name Proteasome 26S subunit non-ATPase 6 (PSMD6) Interacting Protein Interacting Protein Info
UniProt ID
PSMD6_HUMAN 
Synonyms Rpn7; S10; SGA.113M; p42A; p44S10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [8]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [9]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [11]
3 Reconstituted Complex [12]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Reconstituted Complex [14]
References  Top
REF 1 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 2 Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome. J Biol Chem. 2002 Mar 29;277(13):10893-902.
REF 3 Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature. 2009 Jun 11;459(7248):861-5.
REF 4 Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Cell. 2009 May 29;137(5):914-25.
REF 5 MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity. J Biol Chem. 2003 Mar 21;278(12):10668-74.
REF 6 Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol Cell Proteomics. 2017 May;16(5):840-854.
REF 7 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 8 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 9 The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity. Biochem Biophys Res Commun. 2007 Nov 23;363(3):879-84.
REF 10 Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export. Cell Res. 2007 Dec;17(12):1020-9.
REF 11 The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell. 2005 Jul;8(1):75-87.
REF 12 Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene. 2008 Jul 3;27(29):4034-43.
REF 13 Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51.
REF 14 An Interaction Landscape of Ubiquitin Signaling. Mol Cell. 2017 Mar 2;65(5):941-955.e8.

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