Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T53389 Target Info
Target Name TGF-beta receptor type I (TGFBR1)
Synonyms Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TbetaRI; TbetaR-I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; Serine/threonine-protein kinase receptor R4; SKR4; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD; ALK5; ALK-5
Target Type Clinical trial Target
Gene Name TGFBR1
Biochemical Class Kinase
UniProt ID
TGFR1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-localization [4]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Neuropilin-1 (NRP1) Successful Target Interacting Protein Info
UniProt ID
NRP1_HUMAN 
Synonyms VEGF165R; Vascular endothelial cell growth factor 165 receptor; Platelet-derived endothelial cell growth factor receptor; NRP; Membrane-bound; CD304
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Growth factors [+] 1 Growth factors +
Interacting Target Name Transforming growth factor beta 1 (TGFB1) Successful Target Interacting Protein Info
UniProt ID
TGFB1_HUMAN 
Synonyms Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1; TGF-beta1; TGF-beta 1; TGFB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [9]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [10]
Isomerases [+] 1 Isomerases +
Interacting Target Name FK506-binding protein 1A (FKBP1A) Successful Target Interacting Protein Info
UniProt ID
FKB1A_HUMAN 
Synonyms Rotamase; PPIase FKBP1A; Peptidyl-prolyl cis-trans isomerase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP-1A; FKBP-12; FKBP12; FKBP1; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Yeast two hybrid [11]
Kinases [+] 1 Kinases +
Interacting Target Name TGF-beta receptor type II (TGFBR2) Clinical trial Target Interacting Protein Info
UniProt ID
TGFR2_HUMAN 
Synonyms Transforminggrowth factor-beta receptor type II; Transforming growth factor-beta receptor type II; TGFR-2; TGF-beta type II receptor; TGF-beta receptor type-2; TbetaR-II
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [14]
4 Affinity Capture-Western [15]
5 Co-fractionation [16]
6 Yeast two hybrid [17]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Mothers against decapentaplegic homolog 2 (SMAD2) Interacting Protein Interacting Protein Info
UniProt ID
SMAD2_HUMAN 
Synonyms JV18; JV18.1; MADH2; MADR2; hMAD.2; hSMAD2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [20]
4 Biochemical Activity [21]
5 Co-fractionation [16]
Interacting Target Name Mothers against decapentaplegic homolog 7 (SMAD7) Clinical trial Target Interacting Protein Info
UniProt ID
SMAD7_HUMAN 
Synonyms Smad7; SMAD family member 7; SMAD 7; Mothers against DPP homolog 8; Mothers against decapentaplegic homolog 8; MAD homolog 8; hSMAD7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Co-localization [23]
3 Reconstituted Complex [24]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [21]
Other proteins [+] 2 Other proteins +
Interacting Target Name Endoglin CD105 (ENG) Clinical trial Target Interacting Protein Info
UniProt ID
EGLN_HUMAN 
Synonyms END; CD105 antigen; CD105
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Affinity Capture-Western [26]
3 Biochemical Activity [25]
Interacting Target Name Extracellular matrix receptor III (CD44) Clinical trial Target Interacting Protein Info
UniProt ID
CD44_HUMAN 
Synonyms Phagocytic glycoprotein I; Phagocytic glycoprotein 1; PGP-I; PGP-1; MIC4; MDU3; MDU2; LHR; Hyaluronate receptor; HUTCH-I; Hermes antigen; Heparan sulfate proteoglycan; GP90 lymphocyte homing/adhesion receptor; Extracellular matrix receptor-III; Epican; ECMR-III; CDw44; CD44 antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [27]
References  Top
REF 1 RanBPM interacts with TRI, TRAF6 and curbs TGF induced nuclear accumulation of TRI. Cell Signal. 2014 Jan;26(1):162-72.
REF 2 TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell. 2008 Sep 26;31(6):918-24.
REF 3 TNF receptor-associated factor 6 (TRAF6) mediates the angiotensin-induced non-canonical TGF- pathway activation of c-kit(+) cardiac stem cells. Am J Transl Res. 2015 Nov 15;7(11):2233-43.
REF 4 TRAF6 promotes TGF-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGF type I receptor. Cell Cycle. 2015;14(4):554-65.
REF 5 Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. J Biol Chem. 2010 Oct 8;285(41):31840-8.
REF 6 Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta. Carcinogenesis. 2011 Apr;32(4):613-21.
REF 7 Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. Science. 1993 Nov 5;262(5135):900-2.
REF 8 Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31.
REF 9 Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling. J Cell Biochem. 2005 Apr 1;94(5):995-1009.
REF 10 Critical regulation of TGFbeta signaling by Hsp90. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9244-9.
REF 11 Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science. 1994 Jul 29;265(5172):674-6.
REF 12 TSC-22 promotes transforming growth factor -mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Mol Cell Biol. 2011 Sep;31(18):3700-9.
REF 13 Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem. 2009 Aug 14;284(33):22285-96.
REF 14 Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem. 2009 Oct 30;284(44):30097-104.
REF 15 Suppressor of cytokine signaling 1 is a positive regulator of TGF--induced prostaglandin production in human follicular dendritic cell-like cells. J Immunol. 2015 May 1;194(9):4287-97.
REF 16 Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J Biol Chem. 2001 Mar 2;276(9):6727-38.
REF 17 Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor. J Biol Chem. 1995 Mar 10;270(10):5625-30.
REF 18 Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest. 2009 Feb;119(2):349-61.
REF 19 Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003 Jan 24;299(5606):574-7.
REF 20 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-, SMAD2/3, and TAP63 proteins. J Biol Chem. 2013 Jul 5;288(27):19484-502.
REF 21 Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal. 2015 Apr 14;8(372):ra35.
REF 22 Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling. J Biol Chem. 2004 Jul 23;279(30):31568-74.
REF 23 Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor- signaling pathway. J Biol Chem. 2012 Nov 16;287(47):39653-63.
REF 24 The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell. 1997 Jun 27;89(7):1165-73.
REF 25 Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J Biol Chem. 2002 Aug 9;277(32):29197-209.
REF 26 S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology. Circ Res. 2008 Dec 5;103(12):1383-92.
REF 27 Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem. 2002 Oct 18;277(42):39703-12.

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