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Target General Information |
Top |
Target ID |
T52447 |
Target Info
|
Target Name |
Rotamase D (PPID) |
Synonyms |
Peptidylprolyl isomerase D; Peptidyl-prolyl cis-trans isomerase D; PPIase D; Cyclophilin-related protein; Cyclophilin-40; CYP40; CYP-40; 40 kDa peptidyl-prolyl cis-trans isomerase |
Target Type |
Patented-recorded Target |
Gene Name |
PPID |
Biochemical Class |
Cis-trans-isomerase |
UniProt ID |
|
Target Interacting Proteins |
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Heat shock proteins |
[+] 2 Heat shock proteins |
+ |
Interacting Target Name |
Heat shock protein 90 alpha (HSP90A) |
Successful Target |
Interacting Protein Info
|
UniProt ID |
|
Synonyms |
Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa |
Evidence Score (E-score) |
4 Experimental Evidences |
+ |
1 |
Affinity Capture-Western |
[1] |
2 |
Co-purification |
[2] |
3 |
Reconstituted Complex |
[1] |
4 |
Reconstituted Complex |
[3] |
Interacting Target Name |
Heat shock protein 90 beta (HSP90B) |
Clinical trial Target |
Interacting Protein Info
|
UniProt ID |
|
Synonyms |
HSP84; HSP 84; Heat shock 84 kDa |
Evidence Score (E-score) |
2 Experimental Evidences |
+ |
1 |
Co-purification |
[2] |
2 |
Reconstituted Complex |
[4] |
References |
Top |
REF 1 |
S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Lett. 2010 Mar 19;584(6):1119-25.
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REF 2 |
Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40. Anal Biochem. 2011 Mar 15;410(2):257-65.
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REF 3 |
Quantitative assessment of complex formation of nuclear-receptor accessory proteins. Biochem J. 2000 Feb 1;345 Pt 3:627-36.
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REF 4 |
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress Chaperones. 2004 Summer;9(2):167-81.
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