Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T51407 Target Info
Target Name Exportin-1 (XPO1)
Synonyms Exp1; Chromosome region maintenance 1 protein homolog; CRM1
Target Type Clinical trial Target
Gene Name XPO1
Biochemical Class Eukaryotic nuclear pore complex
UniProt ID
XPO1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name ATP-dependent RNA helicase DDX19A (DDX19A) Interacting Protein Interacting Protein Info
UniProt ID
DD19A_HUMAN 
Synonyms DDX19.DDX19L; DDX19L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name MHC class II transactivator (CIITA) Interacting Protein Interacting Protein Info
UniProt ID
C2TA_HUMAN 
Synonyms C2TA; CIITAIV; MHC2TA; NLRA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name NAD-dependent deacetylase sirtuin-2 (SIRT2) Patented-recorded Target Interacting Protein Info
UniProt ID
SIR2_HUMAN 
Synonyms SIR2-like protein 2; SIR2like protein 2; SIR2L2; SIR2L; Regulatory protein SIR2 homolog 2; NAD-dependent protein deacetylase sirtuin-2; NADdependent protein deacetylase sirtuin2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [5]
Kinases [+] 1 Kinases +
Interacting Protein Name STE20-related kinase adapter protein alpha (STRADA) Interacting Protein Interacting Protein Info
UniProt ID
STRAA_HUMAN 
Synonyms LYK5; NY.BR.96; PMSE; STRAD; Stlk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [5]
Membrane-bounded channels [+] 2 Membrane-bounded channels +
Interacting Protein Name Nuclear pore glycoprotein p62 (NUP62) Interacting Protein Interacting Protein Info
UniProt ID
NUP62_HUMAN 
Synonyms IBSN; SNDI; p62
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [6]
Interacting Protein Name Nuclear pore complex protein Nup214 (NUP214) Interacting Protein Interacting Protein Info
UniProt ID
NU214_HUMAN 
Synonyms CAIN; CAN; D9S46E; N214; p250
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [8]
Nuclear RNA exporters [+] 1 Nuclear RNA exporters +
Interacting Protein Name GTP-binding nuclear protein Ran (RAN) Interacting Protein Interacting Protein Info
UniProt ID
RAN_HUMAN 
Synonyms ARA24; Gsp1; TC4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [11]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [5]
Interacting Target Name Transcription regulator protein BACH1 (Bach1) Clinical trial Target Interacting Protein Info
UniProt ID
BACH1_HUMAN 
Synonyms HA2303; BTB and CNC homolog 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [12]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Ran-specific GTPase-activating protein (RANBP1) Interacting Protein Interacting Protein Info
UniProt ID
RANG_HUMAN 
Synonyms HTF9A
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [2]
2 Protein-peptide [5]
3 Reconstituted Complex [11]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Reconstituted Complex [14]
Interacting Protein Name Paxillin (PXN) Interacting Protein Interacting Protein Info
UniProt ID
PAXI_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [5]
Interacting Protein Name Snurportin-1 (SNUPN) Interacting Protein Interacting Protein Info
UniProt ID
SPN1_HUMAN 
Synonyms KPNBL; RNUT1; Snurportin1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [5]
References  Top
REF 1 A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife. 2015 Dec 17;4. pii: e11466.
REF 2 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 3 Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator. J Biol Chem. 2008 Apr 4;283(14):9031-9.
REF 4 The GTP-binding domain of class II transactivator regulates its nuclear export. J Immunol. 2003 Jan 15;170(2):922-30.
REF 5 Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell. 2012 Sep;23(18):3677-93.
REF 6 A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. J Cell Biol. 1999 May 17;145(4):645-57.
REF 7 Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. J Cell Biol. 2001 Jun 25;153(7):1391-402.
REF 8 The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export. J Biol Chem. 2016 Oct 28;291(44):23068-23083.
REF 9 Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting. PLoS Pathog. 2011 Sep;7(9):e1002187.
REF 10 Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. J Cell Sci. 2010 Jan 15;123(Pt 2):192-201.
REF 11 Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. Mol Cell Biol. 2000 May;20(10):3510-21.
REF 12 Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling. Toxicology. 2016 Jul 1;363-364:48-57.
REF 13 Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem. 2002 Apr 26;277(17):14355-8.
REF 14 CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell. 2003 Jan;14(1):201-13.

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