Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T49888 Target Info
Target Name IKK complex-associated protein (IKBKAP)
Synonyms IkappaB kinase complexassociated protein; IkappaB kinase complex-associated protein; IKK complexassociated protein; IKAP; Elongator complex protein 1; ELP1
Target Type Literature-reported Target
Gene Name IKBKAP
UniProt ID
ELP1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Elongator complex protein 3 (ELP3) Interacting Protein Interacting Protein Info
UniProt ID
ELP3_HUMAN 
Synonyms KAT9
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-fractionation [5]
6 Co-fractionation [6]
7 Co-purification [2]
Interacting Protein Name Elongator complex protein 4 (ELP4) Interacting Protein Interacting Protein Info
UniProt ID
ELP4_HUMAN 
Synonyms AN; C11orf19; PAX6NEB; PAXNEB; dJ68P15A.1; hELP4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Co-fractionation [6]
4 Co-purification [2]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Elongator complex protein 2 (ELP2) Interacting Protein Interacting Protein Info
UniProt ID
ELP2_HUMAN 
Synonyms SHINC.2; STATIP1; StIP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Co-fractionation [6]
5 Co-purification [2]
References  Top
REF 1 IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci. 2008 Mar 15;121(Pt 6):854-64.
REF 2 Purification and characterization of the human elongator complex. J Biol Chem. 2002 Jan 25;277(4):3047-52.
REF 3 The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genet. 2009 Oct;5(10):e1000684.
REF 4 Dimerization of elongator protein 1 is essential for Elongator complex assembly. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10697-702.
REF 5 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 6 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.

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