Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T49639 Target Info
Target Name Heat shock protein 70 (HSP70)
Synonyms Heat shock 70 kDa protein; HSP72; HSP70
Target Type Clinical trial Target
Gene Name HSPA1A; HSPA1B
Biochemical Class Heat shock protein
UniProt ID
HS71A_HUMAN; HS71B_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Heat shock proteins [+] 4 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [3]
3 Reconstituted Complex [4]
4 Reconstituted Complex [5]
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [4]
Interacting Protein Name Heat shock 70 kDa protein 1A (HSPA1A) Interacting Protein Interacting Protein Info
UniProt ID
HS71A_HUMAN 
Synonyms HEL.S.103; HSP70.1; HSP70.1A; HSP70I; HSP72; HSPA1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [8]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [10]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [11]
Kinases [+] 1 Kinases +
Interacting Target Name Polo-like kinase 1 (PLK1) Clinical trial Target Interacting Protein Info
UniProt ID
PLK1_HUMAN 
Synonyms STPK13; Serine-threonine protein kinase 13; Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; PLK-1; Plk1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [13]
3 Biochemical Activity [13]
Membrane-bounded channels [+] 2 Membrane-bounded channels +
Interacting Protein Name Importin subunit alpha-3 (KPNA4) Interacting Protein Interacting Protein Info
UniProt ID
IMA3_HUMAN 
Synonyms IPOA3; QIP1; SRP3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [10]
2 Affinity Capture-MS [12]
3 Affinity Capture-MS [10]
Interacting Protein Name Importin subunit alpha-4 (KPNA3) Interacting Protein Interacting Protein Info
UniProt ID
IMA4_HUMAN 
Synonyms IPOA4; SRP1; SRP1gamma; SRP4; hSRP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [10]
2 Affinity Capture-MS [12]
3 Affinity Capture-MS [10]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Heat shock factor protein 2 (HSF2) Interacting Protein Interacting Protein Info
UniProt ID
HSF2_HUMAN 
Synonyms HSF 2; HSTF 2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [10]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [14]
4 Reconstituted Complex [14]
Other proteins [+] 2 Other proteins +
Interacting Protein Name BAG family molecular chaperone regulator 3 (BAG3) Interacting Protein Interacting Protein Info
UniProt ID
BAG3_HUMAN 
Synonyms BAG.3; BIS; CAIR.1; MFM6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [10]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [15]
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [16]
2 Yeast two hybrid [17]
References  Top
REF 1 CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 2003 Oct 15;22(20):5446-58.
REF 2 CHIP interacts with heat shock factor 1 during heat stress. FEBS Lett. 2005 Dec 5;579(29):6559-63.
REF 3 Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry. 2010 Jul 27;49(29):6263-75.
REF 4 A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones. 1996 Dec;1(4):237-50.
REF 5 The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev. 1992 Jul;6(7):1153-64.
REF 6 Methylglyoxal alters the function and stability of critical components of the protein quality control. PLoS One. 2010 Sep 24;5(9):e13007.
REF 7 Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem. 2006 Jan 13;281(2):782-91.
REF 8 Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev. 1998 Mar 1;12(5):654-66.
REF 9 Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L). J Biol Chem. 2011 Sep 9;286(36):31397-408.
REF 10 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 11 Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity. Oncogene. 2009 Sep 17;28(37):3332-44.
REF 12 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
REF 13 HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. Cancer Res. 2008 Sep 15;68(18):7550-60.
REF 14 Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. J Biol Chem. 2003 Sep 12;278(37):35465-75.
REF 15 Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Mol Cell Proteomics. 2013 Oct;12(10):2804-19.
REF 16 The inhibition of CMV promoter by heat shock factor 4b is regulated by Daxx. Int J Biochem Cell Biol. 2010 Oct;42(10):1698-707.
REF 17 DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4100-5.

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