Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T47594 Target Info
Target Name Activin receptor type IB (ACVR1B)
Synonyms Serine/threonine-protein kinase receptor R2; SKR2; Activin receptor-like kinase 4; Activin receptor type-1B; ALK4; ALK-4; ACVRLK4; ACTR-IB
Target Type Patented-recorded Target
Gene Name ACVR1B
Biochemical Class Kinase
UniProt ID
ACV1B_HUMAN 
Target Interacting Proteins  Top
Isomerases [+] 1 Isomerases +
Interacting Target Name FK506-binding protein 1A (FKBP1A) Successful Target Interacting Protein Info
UniProt ID
FKB1A_HUMAN 
Synonyms Rotamase; PPIase FKBP1A; Peptidyl-prolyl cis-trans isomerase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP-1A; FKBP-12; FKBP12; FKBP1; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-Fragment Complementation Assay [2]
Kinases [+] 1 Kinases +
Interacting Target Name Activin receptor type IIB (ACVR2B) Literature-reported Target Interacting Protein Info
UniProt ID
AVR2B_HUMAN 
Synonyms ACTR-IIB; ACTRIIB; Activin receptor type-2B; Activin receptor type2B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-purification [4]
References  Top
REF 1 FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J Mol Endocrinol. 2006 Jun;36(3):569-79.
REF 2 Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells. Nat Methods. 2005 Jun;2(6):427-33.
REF 3 Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. Exp Cell Res. 1996 May 1;224(2):323-34.
REF 4 Activation of signalling by the activin receptor complex. Mol Cell Biol. 1996 Mar;16(3):1066-73.

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