Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47415 | Target Info | |||
| Target Name | HLA class I antigen B-7 (HLA-B) | ||||
| Synonyms | MHC class I antigen B*7; HLAB; HLA class I histocompatibility antigen, B7 alpha chain; HLA class I histocompatibility antigen, B-7 alpha chain | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | HLA-B | ||||
| Biochemical Class | MHC class I | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Beta-2-microglobulin (B2M) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-MS | [2] | |||
| 3 | Co-crystal Structure | [3] | |||
| 4 | Co-crystal Structure | [4] | |||
| 5 | Reconstituted Complex | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 2 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
| REF 3 | Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype. Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1300-10. | ||||
| REF 4 | HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J Biol Chem. 2002 Dec 6;277(49):47844-53. | ||||
| REF 5 | Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading. J Immunol. 2002 Feb 15;168(4):1950-60. | ||||
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