Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T46365 Target Info
Target Name M-phase inducer phosphatase 2 (MPIP2)
Synonyms Dual specificity phosphatase Cdc25B; Cdc25B phosphatase; CDC25HU2
Target Type Clinical trial Target
Gene Name CDC25B
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
MPIP2_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Yeast two hybrid [4]
Kinases [+] 1 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Yeast two hybrid [6]
Proteins 14-3-3 [+] 3 Proteins 14-3-3 +
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [4]
4 Yeast two hybrid [4]
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Yeast two hybrid [4]
4 Yeast two hybrid [6]
Interacting Protein Name 14-3-3 protein epsilon (YWHAE) Interacting Protein Interacting Protein Info
UniProt ID
1433E_HUMAN 
Synonyms 14.3.3E; HEL2; KCIP.1; MDCR; MDS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Yeast two hybrid [6]
Other proteins [+] 1 Other proteins +
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Reconstituted Complex [8]
References  Top
REF 1 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 4 Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase. Oncogene. 2000 Mar 2;19(10):1257-65.
REF 5 Biochemical characterization of Cdk2-Speedy/Ringo A2. BMC Biochem. 2005 Sep 28;6:19.
REF 6 14-3-3 proteins associate with cdc25 phosphatases. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7892-6.
REF 7 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 8 Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. Proc Natl Acad Sci U S A. 2005 May 3;102(18):6279-84.

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