Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T45794 | Target Info | |||
| Target Name | Nuclear receptor coactivator 4 (NCOA4) | ||||
| Synonyms | Ret-activating protein ELE1; RFG; NCoA-4; ELE1; Androgen receptor-associated protein of 70 kDa; Androgen receptor coactivator 70 kDa protein; ARA70 (dARA70N); ARA70; 70 kDa androgen receptor coactivator; 70 kDa AR-activator | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | NCOA4 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | E3 ubiquitin-protein ligase HERC2 (HERC2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | D15F37S1; MRT38; SHEP1; jdf2; p528 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Reconstituted Complex | [2] | |||
| Nuclear hormone receptors | [+] 2 Nuclear hormone receptors | + | |||
| Interacting Target Name | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Protein-peptide | [3] | |||
| 2 | Reconstituted Complex | [4] | |||
| 3 | Yeast two hybrid | [4] | |||
| Interacting Target Name | Androgen receptor (AR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [5] | |||
| 2 | Yeast two hybrid | [6] | |||
| Oxidoreductases | [+] 1 Oxidoreductases | + | |||
| Interacting Target Name | Ferritin (FTH1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PIG15; OK/SW-cl.84; FTHL6; FTH; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein; Cell proliferationinducing gene 15 protein | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [2] | |||
| 2 | Reconstituted Complex | [2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 2 | Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife. 2015 Oct 5;4. | ||||
| REF 3 | T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. | ||||
| REF 4 | Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. J Biol Chem. 1999 Jun 4;274(23):16147-52. | ||||
| REF 5 | Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. Mol Endocrinol. 1999 Jan;13(1):117-28. | ||||
| REF 6 | Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7379-84. | ||||
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