Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T45593 Target Info
Target Name Microtubule-associated protein tau (MAPT)
Synonyms tau; Paired helical filamenttau; Paired helical filament-tau; Neurofibrillary tangle protein; MTBT1; MAPTL
Target Type Clinical trial Target
Gene Name MAPT
UniProt ID
TAU_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Co-purification [8]
9 Protein-peptide [9]
Heat shock proteins [+] 3 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [11]
4 Reconstituted Complex [10]
Interacting Protein Name Heat shock 70 kDa protein 1A (HSPA1A) Interacting Protein Interacting Protein Info
UniProt ID
HS71A_HUMAN 
Synonyms HEL.S.103; HSP70.1; HSP70.1A; HSP70I; HSP72; HSPA1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [10]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [12]
Isomerases [+] 1 Isomerases +
Interacting Target Name Rotamase Pin1 (PIN1) Clinical trial Target Interacting Protein Info
UniProt ID
PIN1_HUMAN 
Synonyms Prolyl isomerase Pin1; PPIase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Reconstituted Complex [14]
Kinases [+] 3 Kinases +
Interacting Target Name Fyn tyrosine protein kinase (FYN) Successful Target Interacting Protein Info
UniProt ID
FYN_HUMAN 
Synonyms Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [16]
3 Reconstituted Complex [15]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [17]
2 Yeast two hybrid [18]
Interacting Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Interacting Protein Info
UniProt ID
GSK3B_HUMAN 
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Reconstituted Complex [11]
Other proteins [+] 1 Other proteins +
Interacting Target Name Synuclein alpha (SNCA) Clinical trial Target Interacting Protein Info
UniProt ID
SYUA_HUMAN 
Synonyms PARK1; Non-A4 component of amyloid precursor; NonA4 component of amyloid precursor; Non-A beta component of AD amyloid; NonA beta component of AD amyloid; NACP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Affinity Capture-Western [21]
3 Co-localization [22]
4 Reconstituted Complex [23]
5 Reconstituted Complex [11]
References  Top
REF 1 Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3622-7.
REF 2 PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS One. 2013;8(3):e58232.
REF 3 CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet. 2004 Apr 1;13(7):703-14.
REF 4 U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J Neurochem. 2004 Oct;91(2):299-307.
REF 5 A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J Biol Chem. 2010 Jul 16;285(29):21978-87.
REF 6 The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest. 2007 Mar;117(3):648-58.
REF 7 Involvement of endoplasmic reticulum stress in tauopathy. Biochem Biophys Res Commun. 2013 Jan 11;430(2):500-4.
REF 8 CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem. 2004 Feb 6;279(6):4869-76.
REF 9 Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics. 2006 Feb;5(2):234-44.
REF 10 Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J. 2013 Apr;27(4):1450-9.
REF 11 Stimulatory effect of -synuclein on the tau-phosphorylation by GSK-3. FEBS J. 2011 Dec;278(24):4895-904.
REF 12 BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. J Biol Chem. 2007 Dec 21;282(51):37276-84.
REF 13 Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions. J Biol Chem. 2006 Feb 17;281(7):4117-25.
REF 14 The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 1999 Jun 24;399(6738):784-8.
REF 15 Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci. 2002 Feb 1;22(3):698-707.
REF 16 Disease-related modifications in tau affect the interaction between Fyn and Tau. J Biol Chem. 2005 Oct 21;280(42):35119-25.
REF 17 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 18 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 19 NUB1 modulation of GSK3 reduces tau aggregation. Hum Mol Genet. 2012 Dec 15;21(24):5254-67.
REF 20 Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation. Exp Cell Res. 2005 Aug 1;308(1):78-84.
REF 21 Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem. 2011 Feb 18;286(7):5055-68.
REF 22 alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton. Neurobiol Dis. 2007 Jun;26(3):521-31.
REF 23 alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem. 1999 Sep 3;274(36):25481-9.

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