Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T44589 Target Info
Target Name Interleukin 3 receptor (CSF2RB)
Synonyms IL5RB; IL3RB; IL-5R; GM-CSF/IL-3/IL-5 receptor common beta subunit; Cytokine receptor common subunit beta; CDw131; CD131
Target Type Clinical trial Target
Gene Name CSF2RB
Biochemical Class Cytokine receptor
UniProt ID
IL3RB_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6) Patented-recorded Target Interacting Protein Info
UniProt ID
PTN6_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Kinases [+] 1 Kinases +
Interacting Target Name Tyrosine-protein kinase Lyn (JTK8) Clinical trial Target Interacting Protein Info
UniProt ID
LYN_HUMAN 
Synonyms V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p56Lyn; p53Lyn; Lck/Yes-related novel protein tyrosine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Protein-peptide [3]
References  Top
REF 1 SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates. J Biol Chem. 1997 May 30;272(22):14470-6.
REF 2 Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e). J Immunol. 1995 Aug 15;155(4):2165-74.
REF 3 The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162(3):1496-501.

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