Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T44516 Target Info
Target Name Voltage-gated potassium channel Kv2.1 (KCNB1)
Synonyms Voltage-gated potassium channel subunit Kv2.1; Rectifier potassium channel Kv2.1; Potassium voltage-gated channel subfamily B member 1; Potassium channel Kv2.1; H-DRK1; DRK1
Target Type Literature-reported Target
Gene Name KCNB1
Biochemical Class Voltage-gated ion channel
UniProt ID
KCNB1_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Protein Name Potassium voltage-gated channel subfamily G member 3 (KCNG3) Interacting Protein Interacting Protein Info
UniProt ID
KCNG3_HUMAN 
Synonyms KV10.1; KV6.3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Fluorescence Resonance Energy Transfer [2]
3 Yeast two hybrid [1]
4 Yeast two hybrid [2]
Vesicle fusion pores [+] 1 Vesicle fusion pores +
Interacting Protein Name Syntaxin-1A (STX1A) Interacting Protein Interacting Protein Info
UniProt ID
STX1A_HUMAN 
Synonyms HPC.1; P35.1; STX1; SYN1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
References  Top
REF 1 Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7986-91.
REF 2 Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem. 2009 Feb 13;284(7):4695-704.
REF 3 The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function. Diabetologia. 2012 Jun;55(6):1709-20.
REF 4 Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels. Biochem J. 2005 Apr 1;387(Pt 1):195-202.

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