Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T41646 Target Info
Target Name Beta-arrestin-1 (ARRB1)
Synonyms Non-visual arrestin-2; Betaarrestin1; Arrestin beta1; Arrestin beta-1; ARR1
Target Type Literature-reported Target
Gene Name ARRB1
Biochemical Class Arrestin protein
UniProt ID
ARRB1_HUMAN 
Target Interacting Proteins  Top
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Adrenergic receptor beta-1 (ADRB1) Successful Target Interacting Protein Info
UniProt ID
ADRB1_HUMAN 
Synonyms Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Kinases [+] 4 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [3]
2 Protein-Fragment Complementation Assay [3]
3 Yeast two hybrid [4]
Interacting Target Name Apoptosis signal-regulating kinase 1 (MAP3K5) Clinical trial Target Interacting Protein Info
UniProt ID
M3K5_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 5; MEKK5; MEKK 5; MEK kinase 5; MAPKKK5; MAPK/ERK kinase kinase 5; ASK-1; ASK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Protein-peptide [6]
Interacting Target Name Stress-activated protein kinase JNK3 (JNK3) Patented-recorded Target Interacting Protein Info
UniProt ID
MK10_HUMAN 
Synonyms Stress-activated protein kinase 1b; SAPK1b; PRKM10; Mitogen-activated protein kinase 10; MAPK 10; MAP kinase p49 3F12; MAP kinase 10; JNK3A; C-Jun N-terminal kinase 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Protein-peptide [6]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) Interacting Protein Interacting Protein Info
UniProt ID
P85B_HUMAN 
Synonyms MPPH; MPPH1; P85B; p85; p85.BETA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Yeast two hybrid [9]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name Glycine N-methyltransferase (GNMT) Interacting Protein Interacting Protein Info
UniProt ID
GNMT_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Yeast two hybrid [10]
3 Yeast two hybrid [9]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Yeast two hybrid [12]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Nucleolar and coiled-body phosphoprotein 1 (NOLC1) Interacting Protein Interacting Protein Info
UniProt ID
NOLC1_HUMAN 
Synonyms NOPP130; NOPP140; NS5ATP13; P130
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [13]
3 Affinity Capture-MS [14]
4 Affinity Capture-Western [8]
Interacting Protein Name Treacle protein (TCOF1) Interacting Protein Interacting Protein Info
UniProt ID
TCOF_HUMAN 
Synonyms MFD1; TCS; TCS1; treacle
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [13]
3 Affinity Capture-MS [14]
4 Affinity Capture-Western [8]
Interacting Protein Name NF-kappa-B inhibitor alpha (NFKBIA) Interacting Protein Interacting Protein Info
UniProt ID
IKBA_HUMAN 
Synonyms IKBA; MAD.3; NFKBI
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Yeast two hybrid [15]
Interacting Protein Name Zinc finger Ran-binding domain-containing protein 2 (ZRANB2) Interacting Protein Interacting Protein Info
UniProt ID
ZRAB2_HUMAN 
Synonyms ZIS; ZIS1; ZIS2; ZNF265
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [14]
3 Affinity Capture-Western [8]
Interacting Protein Name Clathrin heavy chain 1 (CLTC) Interacting Protein Interacting Protein Info
UniProt ID
CLH1_HUMAN 
Synonyms CHC; CHC17; CLH.17; CLTCL2; Hc
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [17]
References  Top
REF 1 Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14555-60.
REF 2 Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors. J Biol Chem. 2000 Sep 15;275(37):29082-90.
REF 3 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 4 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 5 beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis. Cell Signal. 2009 Jul;21(7):1195-206.
REF 6 A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. FEBS Lett. 2009 Oct 20;583(20):3310-6.
REF 7 Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. J Biol Chem. 2001 Jul 27;276(30):27770-7.
REF 8 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6.
REF 9 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 10 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 11 Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem. 2003 Mar 28;278(13):11648-53.
REF 12 Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science. 2001 Nov 9;294(5545):1307-13.
REF 13 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 14 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 15 beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8603-7.
REF 16 Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol Cell. 2004 May 7;14(3):303-17.
REF 17 Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J Immunol. 2006 Jun 1;176(11):7039-50.

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