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| Target General Information |
Top |
| Target ID |
T41119 |
Target Info
|
| Target Name |
Early response protein NAK1 (NR4A1) |
| Synonyms |
Testicular receptor 3; ST-59; Orphan nuclear receptor TR3; Orphan nuclear receptor HMR; Nur77; Nuclear receptor subfamily 4 group A member 1; Nuclear hormone receptor NUR/77; NAK1; GFRP1 |
| Target Type |
Literature-reported Target |
| Gene Name |
NR4A1 |
| Biochemical Class |
Nuclear hormone receptor |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Auxiliary transporters |
[+] 1 Auxiliary transporters |
+ |
| Interacting Target Name |
Apoptosis regulator Bcl-2 (BCL-2) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Bcl-2; Apoptosis regulator Bcl-2 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[1] |
| 3 |
Yeast two hybrid |
[1] |
| Nuclear hormone receptors |
[+] 1 Nuclear hormone receptors |
+ |
| Interacting Target Name |
Retinoic acid receptor RXR-alpha (RXRA) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1 |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[2] |
| 2 |
Reconstituted Complex |
[1] |
| 3 |
Reconstituted Complex |
[3] |
| 4 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 2004 Feb 20;116(4):527-40.
|
| REF 2 |
Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha. Mol Endocrinol. 2007 Dec;21(12):2877-89.
|
| REF 3 |
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 1995 Apr 1;9(7):769-82.
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