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| Target General Information |
Top |
| Target ID |
T40890 |
Target Info
|
| Target Name |
Zinc finger protein GLI1 (Gli1) |
| Synonyms |
Oncogene GLI; Glioma-associated oncogene; GLI |
| Target Type |
Patented-recorded Target |
| Gene Name |
GLI1 |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 2 Other proteins |
+ |
| Interacting Protein Name |
Suppressor of fused homolog (SUFU) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
PRO1280; SUFUH; SUFUXL |
| Evidence Score (E-score) |
5 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Affinity Capture-Western |
[3] |
| 4 |
Far Western |
[3] |
| 5 |
Reconstituted Complex |
[2] |
| Interacting Protein Name |
THO complex subunit 4 (ALYREF) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
ALY; ALY/REF; BEF; REF; THOC4 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[4] |
| 2 |
Affinity Capture-MS |
[1] |
| References |
Top |
| REF 1 |
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
|
| REF 2 |
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J Cell Sci. 1999 Dec;112 ( Pt 23):4437-48.
|
| REF 3 |
Characterization of the physical interaction of Gli proteins with SUFU proteins. J Biol Chem. 2003 Feb 14;278(7):5116-22.
|
| REF 4 |
Active IKK promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. Blood. 2016 Feb 4;127(5):605-15.
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