Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40276 | Target Info | |||
| Target Name | Protein kinase C beta (PRKCB) | ||||
| Synonyms | Protein kinase C beta type; PRKCB1; PKCB; PKC-beta; PKC-B | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PRKCB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Target Name | Linear ubiquitin chain assembly complex (RBCK1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | XAP4; XAP3; Ubiquitin-conjugating enzyme 7-interacting protein 3; UBCE7IP3; RNF54; RING-type E3 ubiquitin transferase HOIL-1; RING finger protein 54; RanBP-type and C3HC4-type zinc finger-containing protein 1; HOIL-1; Hepatitis B virus X-associated protein 4; Heme-oxidized IRP2 ubiquitin ligase 1; HBV-associated factor 4; C20orf18 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Biochemical Activity | [3] | |||
| Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
| Interacting Target Name | Receptor of activated protein C kinase 1 (RACK1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Small ribosomal subunit protein RACK1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor for activated C kinase; Human lung cancer oncogene 7 protein; HLC-7; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; GNB2L1; Cell proliferation-inducing gene 21 protein | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Reconstituted Complex | [5] | |||
| Intermediate filaments | [+] 1 Intermediate filaments | + | |||
| Interacting Protein Name | Lamin-B1 (LMNB1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ADLD; LMN; LMN2; LMNB | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Biochemical Activity | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. J Biol Chem. 2007 Jan 19;282(3):1650-7. | ||||
| REF 2 | Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex. Biochem Biophys Res Commun. 2006 Dec 15;351(2):340-7. | ||||
| REF 3 | Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. J Biol Chem. 2008 Apr 25;283(17):11575-85. | ||||
| REF 4 | Coordinated movement of RACK1 with activated betaIIPKC. J Biol Chem. 1999 Sep 17;274(38):27039-46. | ||||
| REF 5 | The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway. Oncogene. 2015 Mar 5;34(10):1280-91. | ||||
| REF 6 | Protein kinase C-beta II Is an apoptotic lamin kinase in polyomavirus-transformed, etoposide-treated pyF111 rat fibroblasts. J Biol Chem. 2002 May 24;277(21):18827-39. | ||||
| REF 7 | Identification of nuclear beta II protein kinase C as a mitotic lamin kinase. J Biol Chem. 1994 Jul 22;269(29):19074-80. | ||||
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