Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T39738 Target Info
Target Name Cullin-7 (CUL-7)
Synonyms KIAA0076
Target Type Literature-reported Target
Gene Name CUL7
UniProt ID
CUL7_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RBX1 (RBX1) Interacting Protein Interacting Protein Info
UniProt ID
RBX1_HUMAN 
Synonyms BA554C12.1; RNF75; ROC1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Reconstituted Complex [2]
Histones [+] 1 Histones +
Interacting Protein Name Histone H2B type 2-E (HIST2H2BE) Interacting Protein Interacting Protein Info
UniProt ID
H2B2E_HUMAN 
Synonyms GL105; H2B; H2B.1; H2BFQ; H2BGL105; H2BQ
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [10]
7 Affinity Capture-Western [11]
8 Reconstituted Complex [12]
9 Reconstituted Complex [11]
10 Yeast two hybrid [8]
Other proteins [+] 2 Other proteins +
Interacting Protein Name F-box/WD repeat-containing protein 8 (FBXW8) Interacting Protein Interacting Protein Info
UniProt ID
FBXW8_HUMAN 
Synonyms FBW6; FBW8; FBX29; FBXO29; FBXW6
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [13]
5 Affinity Capture-Western [14]
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [13]
References  Top
REF 1 Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination. J Biol Chem. 2012 Nov 23;287(48):40758-66.
REF 2 CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16601-6.
REF 3 Identification of mutations in CUL7 in 3-M syndrome. Nat Genet. 2005 Oct;37(10):1119-24.
REF 4 Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Oncogene. 2006 Aug 3;25(33):4534-48.
REF 5 Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. Structure. 2015 Apr 7;23(4):700-12.
REF 6 Identifying biological pathways that underlie primordial short stature using network analysis. J Mol Endocrinol. 2014 Jun;52(3):333-44.
REF 7 CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression. J Cell Sci. 2018 Apr 26;131(8). pii: jcs213868.
REF 8 Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding. Biochim Biophys Acta. 2007 Mar;1773(3):358-66.
REF 9 PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007 Mar 1;67(5):2006-14.
REF 10 CUL7 is a novel antiapoptotic oncogene. Cancer Res. 2007 Oct 15;67(20):9616-22.
REF 11 A novel p53-binding domain in CUL7. Biochem Biophys Res Commun. 2006 Sep 15;348(1):132-8.
REF 12 The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. J Biol Chem. 2007 Apr 13;282(15):11300-7.
REF 13 Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol. 2008 Jan;28(2):743-51.
REF 14 The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell. 2008 May 23;30(4):403-14.

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