Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39519 | Target Info | |||
| Target Name | Lysine N-methyltransferase 1A (SUV39H1) | ||||
| Synonyms | Suppressor of variegation 3-9 homolog 1; Su(var)3-9 homolog 1; SUV39H; Position-effect variegation 3-9 homolog; KMT1A; Histone-lysine N-methyltransferase SUV39H1; Histone H3-K9 methyltransferase 1; H3-K9-HMTase 1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SUV39H1 | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | E3 SUMO-protein ligase CBX4 (CBX4) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | NBP16; PC2 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Biochemical Activity | [2] | |||
| 3 | Yeast two hybrid | [1] | |||
| One-carbon transferases | [+] 1 One-carbon transferases | + | |||
| Interacting Protein Name | Histone-lysine N-methyltransferase MECOM (MECOM) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | AML1.EVI.1; EVI1; MDS1; MDS1.EVI1; PRDM3 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Reconstituted Complex | [3] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Protein Name | Runt-related transcription factor 1 (RUNX1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | AML1; AML1.EVI.1; AMLCR1; CBFA2; EVI.1; PEBP2aB | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Affinity Capture-Western | [6] | |||
| 3 | Co-purification | [6] | |||
| 4 | Reconstituted Complex | [5] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Protein Name | Chromobox protein homolog 5 (CBX5) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HEL25; HP1; HP1A | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [7] | |||
| 2 | Affinity Capture-MS | [8] | |||
| 3 | Yeast two hybrid | [9] | |||
| 4 | Yeast two hybrid | [10] | |||
| Interacting Protein Name | Chromobox protein homolog 1 (CBX1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CBX; HP1.BETA; HP1Hs.beta; HP1Hsbeta; M31; MOD1; p25beta | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [8] | |||
| 2 | Affinity Capture-Western | [11] | |||
| 3 | Co-fractionation | [11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Mol Cell Biol. 2002 Aug;22(15):5539-53. | ||||
| REF 2 | ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 2011 Nov 11;147(4):773-88. | ||||
| REF 3 | EVI1 recruits the histone methyltransferase SUV39H1 for transcription repression. J Cell Biochem. 2008 Oct 1;105(2):344-52. | ||||
| REF 4 | A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. FEBS Lett. 2008 Aug 6;582(18):2761-7. | ||||
| REF 5 | SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. Oncogene. 2003 Aug 14;22(34):5229-37. | ||||
| REF 6 | RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. Oncogene. 2006 Sep 21;25(42):5777-86. | ||||
| REF 7 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 8 | A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. | ||||
| REF 9 | Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8. | ||||
| REF 10 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
| REF 11 | Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38. | ||||
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