Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T39486 Target Info
Target Name Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2)
Synonyms Dual specificity tyrosine-phosphorylation-regulated kinase 2
Target Type Patented-recorded Target
Gene Name DYRK2
Biochemical Class Kinase
UniProt ID
DYRK2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase UBR5 (UBR5) Interacting Protein Interacting Protein Info
UniProt ID
UBR5_HUMAN 
Synonyms DD5; EDD; EDD1; HYD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [1]
Kinases [+] 1 Kinases +
Interacting Protein Name DDB1- and CUL4-associated factor 1 (DCAF1) Interacting Protein Interacting Protein Info
UniProt ID
DCAF1_HUMAN 
Synonyms DCAF1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [1]
Other proteins [+] 1 Other proteins +
Interacting Protein Name DNA damage-binding protein 1 (DDB1) Interacting Protein Interacting Protein Info
UniProt ID
DDB1_HUMAN 
Synonyms DDBA; UV.DDB1; XAP1; XPCE; XPE; XPE.BF
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [1]
References  Top
REF 1 Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol. 2009 Apr;11(4):409-19.
REF 2 Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1VprBP. EMBO Rep. 2017 Apr;18(4):632-644.

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