Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T39231 Target Info
Target Name Tankyrase-1 (TNKS-1)
Synonyms Tankyrase I; TRF1-interacting ankyrin-related ADP-ribose polymerase; TNKS1; TINF1; TIN1; TANK1; Protein poly-ADP-ribosyltransferase tankyrase-1; Poly [ADP-ribose] polymerase tankyrase-1; Poly [ADP-ribose] polymerase 5A; PARPL; PARP5A; ARTD5; ADP-ribosyltransferase diphtheria toxin-like 5
Target Type Clinical trial Target
Gene Name TNKS
Biochemical Class Glycosyltransferases
UniProt ID
TNKS1_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Telomeric repeat-binding factor 1 (TERF1) Literature-reported Target Interacting Protein Info
UniProt ID
TERF1_HUMAN 
Synonyms TTAGGG repeat-binding factor 1; TRF1; TRF; TRBF1; Telomeric protein Pin2/TRF1; PIN2; NIMA-interacting protein 2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [1]
3 Biochemical Activity [2]
4 Biochemical Activity [3]
5 Co-purification [2]
6 Yeast two hybrid [4]
References  Top
REF 1 Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol. 2002 Jan;22(1):332-42.
REF 2 TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet. 2004 Jun;36(6):618-23.
REF 3 Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science. 1998 Nov 20;282(5393):1484-7.
REF 4 The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). J Biol Chem. 2002 Apr 19;277(16):14116-26.

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