Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T38745 | Target Info | |||
Target Name | DNA fragmentation factor alpha (DFFA) | ||||
Synonyms | Inhibitor of caspase-3-activated Dnase; Inhibitor of CAD; ICAD; H13; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; DFF45; DFF1; DFF-45 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | DFFA | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Ester hydrolases | [+] 1 Ester hydrolases | + | |||
Interacting Target Name | Caspase-activated deoxyribonuclease (DFFB) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DFFB; DFF-40; CPAN; Caspase-activated nuclease; Caspase-activated DNase; Caspase-activated deoxyribonuclease | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Affinity Capture-Western | [4] | |||
Peptidases | [+] 1 Peptidases | + | |||
Interacting Target Name | Caspase-3 (CASP3) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [5] | |||
2 | Co-localization | [6] |
References | Top | ||||
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REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 2 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
REF 3 | Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89. | ||||
REF 4 | Study of DFF45 in its role of chaperone and inhibitor: two independent inhibitory domains of DFF40 nuclease activity. Biochem Biophys Res Commun. 1999 Oct 14;264(1):176-80. | ||||
REF 5 | Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12815-9. | ||||
REF 6 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. |
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