Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T38610 Target Info
Target Name Alpha-crystallin A chain (CRYAA)
Synonyms HspB4; Heat shock protein beta-4; CRYA1
Target Type Literature-reported Target
Gene Name CRYAA
Biochemical Class Heat shock protein
UniProt ID
CRYAA_HUMAN 
Target Interacting Proteins  Top
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Protein Name Alpha-crystallin B chain (CRYAB) Interacting Protein Interacting Protein Info
UniProt ID
CRYAB_HUMAN 
Synonyms CMD1II; CRYA2; CTPP2; CTRCT16; HEL.S.101; HSPB5; MFM2
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Fluorescence Resonance Energy Transfer [2]
3 Fluorescence Resonance Energy Transfer [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [2]
6 Reconstituted Complex [5]
7 Reconstituted Complex [6]
8 Reconstituted Complex [3]
9 Yeast two hybrid [7]
10 Yeast two hybrid [8]
11 Yeast two hybrid [1]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [1]
3 Yeast two hybrid [1]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Beta-crystallin A3 (CRYBA1) Interacting Protein Interacting Protein Info
UniProt ID
CRBA1_HUMAN 
Synonyms CRYB1; CTRCT10
Evidence Score (E-score) 6 Experimental Evidences +
1 Co-localization [9]
2 Fluorescence Resonance Energy Transfer [9]
3 Fluorescence Resonance Energy Transfer [3]
4 Reconstituted Complex [9]
5 Reconstituted Complex [3]
6 Yeast two hybrid [9]
References  Top
REF 1 Alteration of protein-protein interactions of congenital cataract crystallin mutants. Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1155-9.
REF 2 Oligomerization with wt A- and B-crystallins reduces proteasome-mediated degradation of C-terminally truncated A-crystallin. Invest Ophthalmol Vis Sci. 2012 May 4;53(6):2541-50.
REF 3 Interaction of A3-Crystallin with Deamidated Mutants of A- and B-Crystallins. PLoS One. 2015 Dec 11;10(12):e0144621.
REF 4 Anti-chaperone betaA3/A1(102-117) peptide interacting sites in human alphaB-crystallin. Mol Vis. 2008 Mar 26;14:666-74.
REF 5 Study of subunit interactions of alpha A- and alpha B-crystallins and the effects of gamma-irradiation on their interactions by surface plasmon resonance. Biochim Biophys Acta. 2008 Nov;1784(11):1507-13.
REF 6 Temperature-dependent structural and functional properties of a mutant (F71L) A-crystallin: molecular basis for early onset of age-related cataract. FEBS Lett. 2011 Dec 15;585(24):3884-9.
REF 7 Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay. J Biol Chem. 2002 Feb 8;277(6):4255-60.
REF 8 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 9 Identification of interaction sites between human betaA3- and alphaA/alphaB-crystallins by mammalian two-hybrid and fluorescence resonance energy transfer acceptor photobleaching methods. J Biol Chem. 2009 Jul 3;284(27):18481-92.

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