Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T38087 Target Info
Target Name Tankyrase-2 (TNKS-2)
Synonyms Tankyrase-related protein; Tankyrase-like protein; Tankyrase II; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; TNKL; TANK2; Protein poly-ADP-ribosyltransferase tankyrase-2; Poly [ADP-ribose] polymerase tankyrase-2; Poly [ADP-ribose] polymerase 5B; PARP5B; ARTD6; ADP-ribosyltransferase diphtheria toxin-like 6
Target Type Clinical trial Target
Gene Name TNKS2
Biochemical Class Glycosyltransferases
UniProt ID
TNKS2_HUMAN 
Target Interacting Proteins  Top
Peptidases [+] 1 Peptidases +
Interacting Target Name Leucyl-cysteinyl aminopeptidase (LNPEP) Patented-recorded Target Interacting Protein Info
UniProt ID
LCAP_HUMAN 
Synonyms P-LAP; Placental leucine aminopeptidase; Oxytocinase; OTase; Leucyl-cystinyl aminopeptidase; IRAP; Insulin-responsive aminopeptidase; Insulin-regulated membrane aminopeptidase; Cystinyl aminopeptidase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [3]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Telomeric repeat-binding factor 1 (TERF1) Literature-reported Target Interacting Protein Info
UniProt ID
TERF1_HUMAN 
Synonyms TTAGGG repeat-binding factor 1; TRF1; TRF; TRBF1; Telomeric protein Pin2/TRF1; PIN2; NIMA-interacting protein 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [3]
Other proteins [+] 1 Other proteins +
Interacting Protein Name SH3 domain-binding protein 2 (SH3BP2) Interacting Protein Interacting Protein Info
UniProt ID
3BP2_HUMAN 
Synonyms 3BP.2; 3BP2; CRBM; CRPM
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Co-crystal Structure [6]
References  Top
REF 1 Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J. 2002 Feb 1;361(Pt 3):451-9.
REF 2 Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a nov... J Biol Chem. 2002 Aug 30;277(35):31887-92.
REF 3 Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J Biol Chem. 2000 Dec 8;275(49):38437-44.
REF 4 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 5 Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell. 2011 Dec 9;147(6):1324-39.
REF 6 Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell. 2011 Dec 9;147(6):1340-54.

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