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| Target General Information |
Top |
| Target ID |
T37539 |
Target Info
|
| Target Name |
B-cell receptor CD22 (CD22) |
| Synonyms |
T-cell surface antigen Leu-14; Siglec-2; Sialic acid-binding Ig-like lectin 2; SIGLEC2; Leu-14; BL-CAM; B-lymphocyte cell adhesion molecule |
| Target Type |
Successful Target |
| Gene Name |
CD22 |
| Biochemical Class |
Immunoglobulin |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Ester hydrolases |
[+] 1 Ester hydrolases |
+ |
| Interacting Target Name |
Protein-tyrosine phosphatase SHP-1 (PTPN6) |
Patented-recorded Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[2] |
| References |
Top |
| REF 1 |
SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem. 2001 Jul 13;276(28):26648-55.
|
| REF 2 |
Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22. J Biol Chem. 1999 Jan 22;274(4):2303-7.
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