Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T36741 Target Info
Target Name p53-binding protein Mdm4 (MDM4)
Synonyms Protein Mdmx; Mdm2-like p53-binding protein; Double minute 4 protein
Target Type Clinical trial Target
Gene Name MDM4
Biochemical Class MDM2/MDM4 family
UniProt ID
MDM4_HUMAN 
Target Interacting Proteins  Top
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Fluorescence Resonance Energy Transfer [3]
4 Protein-Fragment Complementation Assay [4]
5 Protein-peptide [5]
6 Reconstituted Complex [2]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Co-crystal Structure [8]
4 Protein-peptide [9]
5 Reconstituted Complex [10]
6 Yeast two hybrid [11]
Other proteins [+] 1 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Co-fractionation [13]
3 Reconstituted Complex [13]
References  Top
REF 1 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 2 A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16;18(5):411-22.
REF 3 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 4 A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11;9(5):1946-1958.
REF 5 Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene. 2016 Apr 14;35(15):1919-25.
REF 6 Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7. EMBO Rep. 2018 Feb;19(2):305-319.
REF 7 Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell. 2009 Aug 14;35(3):316-26.
REF 8 Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ. 2008 May;15(5):841-8.
REF 9 Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy. Cancer Res. 2015 Nov 1;75(21):4560-72.
REF 10 HDMX folds the nascent p53 mRNA following activation by the ATM kinase. Mol Cell. 2014 May 8;54(3):500-11.
REF 11 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 12 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53. J Biol Chem. 2011 Feb 18;286(7):5136-42.
REF 13 MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol. 2008 Feb;28(4):1218-29.

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