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| Target General Information |
Top |
| Target ID |
T36483 |
Target Info
|
| Target Name |
Proteinase activated receptor 1 (F2R) |
| Synonyms |
Thrombin receptor; Proteinase-activated receptor 1; Protease-activated receptor-1; Protease activated receptor 1; PAR1; PAR-1; Coagulation factor II receptor; CF2R |
| Target Type |
Successful Target |
| Gene Name |
F2R |
| Biochemical Class |
GPCR rhodopsin |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Auxiliary transporters |
[+] 1 Auxiliary transporters |
+ |
| Interacting Target Name |
Caveolin 1 (CAV1) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Caveolin-1; Caveolin1; Cav-1; CAV |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Co-fractionation |
[1] |
| References |
Top |
| REF 1 |
Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J Thromb Haemost. 2007 Dec;5(12):2437-44.
|
| REF 2 |
Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J Biol Chem. 2010 Nov 5;285(45):34803-12.
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