Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T36075 Target Info
Target Name Glucagon-like peptide 1 receptor (GLP1R)
Synonyms GLP-1R; GLP-1-R; GLP-1 receptor
Target Type Successful Target
Gene Name GLP1R
Biochemical Class GPCR secretin
UniProt ID
GLP1R_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Protein Name CD81 antigen (CD81) Interacting Protein Interacting Protein Info
UniProt ID
CD81_HUMAN 
Synonyms CVID6; S5.7; TAPA1; TSPAN28
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-Fragment Complementation Assay [1]
3 Protein-Fragment Complementation Assay [2]
Interacting Protein Name Interferon-induced transmembrane protein 3 (IFITM3) Interacting Protein Interacting Protein Info
UniProt ID
IFM3_HUMAN 
Synonyms 1.8U; DSPA2b; IP15
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-Fragment Complementation Assay [1]
3 Protein-Fragment Complementation Assay [3]
Porters [+] 1 Porters +
Interacting Target Name Solute carrier family 15 member 4 (SLC15A4) Literature-reported Target Interacting Protein Info
UniProt ID
S15A4_HUMAN 
Synonyms SLC15A4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-Fragment Complementation Assay [1]
3 Protein-Fragment Complementation Assay [2]
Other proteins [+] 1 Other proteins +
Interacting Target Name Glucagon (GCG) Clinical trial Target Interacting Protein Info
UniProt ID
GLUC_HUMAN 
Synonyms GLP1; GLP2; GRPP; GLP-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [4]
2 Reconstituted Complex [5]
References  Top
REF 1 The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. Mol Endocrinol. 2013 Sep;27(9):1550-63.
REF 2 A Novel Interacting Protein SERP1 Regulates the N-Linked Glycosylation and Function of GLP-1 Receptor in the Liver. J Cell Biochem. 2017 Nov;118(11):3616-3626.
REF 3 A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. J Biol Chem. 2015 Oct 9;290(41):25045-61.
REF 4 High yield production of recombinant native and modified peptides exemplified by ligands for G-protein coupled receptors. Protein Expr Purif. 2008 Mar;58(1):114-21.
REF 5 Characterization of glucagon-like peptide-1 receptor-binding determinants. J Mol Endocrinol. 2000 Dec;25(3):321-35.

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