Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T35161 Target Info
Target Name Heat shock protein beta-8 (HSPB8)
Synonyms Small stress proteinlike protein HSP22; Small stress protein-like protein HSP22; Protein kinase H11; PP1629; HspB8; Heat shock protein beta8; HSP22; E2induced gene 1 protein; E2IG1; E2-induced gene 1 protein; CRYAC; Alphacrystallin C chain; Alpha-crystallin C chain
Target Type Literature-reported Target
Gene Name HSPB8
Biochemical Class Heat shock protein
UniProt ID
HSPB8_HUMAN 
Target Interacting Proteins  Top
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Protein Name Heat shock protein beta-7 (HSPB7) Interacting Protein Interacting Protein Info
UniProt ID
HSPB7_HUMAN 
Synonyms cvHSP
Evidence Score (E-score) 3 Experimental Evidences +
1 Yeast two hybrid [1]
2 Yeast two hybrid [2]
3 Yeast two hybrid [3]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Yeast two hybrid [1]
Other proteins [+] 1 Other proteins +
Interacting Protein Name BAG family molecular chaperone regulator 3 (BAG3) Interacting Protein Interacting Protein Info
UniProt ID
BAG3_HUMAN 
Synonyms BAG.3; BIS; CAIR.1; MFM6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Yeast two hybrid [6]
References  Top
REF 1 Interaction of human HSP22 (HSPB8) with other small heat shock proteins. J Biol Chem. 2004 Jan 23;279(4):2394-402.
REF 2 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 3 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 4 Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. Nat Genet. 2004 Jun;36(6):597-601.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.

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