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| Target General Information |
Top |
| Target ID |
T35040 |
Target Info
|
| Target Name |
Basigin (BSG) |
| Synonyms |
UNQ6505/PRO21383; Tumor cell-derived collagenase stimulatory factor; TCSF; OK blood group antigen; Leukocyte activation antigen M6; Extracellular matrix metalloproteinase inducer; EMMPRIN; 5F7 |
| Target Type |
Clinical trial Target |
| Gene Name |
BSG |
| Biochemical Class |
Basigin protein |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Porters |
[+] 1 Porters |
+ |
| Interacting Target Name |
Monocarboxylate transporter 1 (SLC16A1) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Solute carrier family 16 member 1; MCT1; MCT 1 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Affinity Capture-Western |
[3] |
| References |
Top |
| REF 1 |
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 2000 Aug 1;19(15):3896-904.
|
| REF 2 |
Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Mol Biol Cell. 2012 Dec;23(24):4668-78.
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| REF 3 |
Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nat Med. 2016 Jul;22(7):735-43.
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