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| Target General Information |
Top |
| Target ID |
T33976 |
Target Info
|
| Target Name |
Transferrin receptor protein 1 (TFRC) |
| Synonyms |
Trfr; TfR1; TfR; TR protein; T9; P90; CD71 antigen; CD71 |
| Target Type |
Clinical trial Target |
| Gene Name |
TFRC |
| Biochemical Class |
Peptidase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Protein Name |
Hereditary hemochromatosis protein (HFE) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
HFE1; HH; HLA.H; MVCD7; TFQTL2 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1472-7.
|
| REF 2 |
Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem. 2000 Dec 8;275(49):38135-8.
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