Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32348 | Target Info | |||
| Target Name | Early growth response protein 1 (EGR-1) | ||||
| Synonyms | Zinc finger protein Krox24; Zinc finger protein Krox-24; Zinc finger protein 225; ZNF225; Transcription factor Zif268; Transcription factor ETR103; Nerve growth factorinduced protein A; Nerve growth factor-induced protein A; NGFIA; NGFI-A; KROX24; AT225 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | EGR1 | ||||
| Biochemical Class | EGR C2H2-type zinc-finger | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Target Name | Histone acetyltransferase p300 (EP300) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [3] | |||
| 4 | Reconstituted Complex | [3] | |||
| Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
| Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Reconstituted Complex | [4] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Target Name | CCAAT/enhancer binding protein beta (CEBPB) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor CCAAT/enhancer-binding protein beta; Transcription factor 5; TCF-5; TCF5; PP9092; Nuclear factor NF-IL6; Liver-enriched inhibitory protein; Liver activator protein; LIP; LAP; CCAAT/enhancer-binding protein beta; C/EBP beta | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Reconstituted Complex | [6] | |||
| 3 | Yeast two hybrid | [6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell. 2004 Jul 2;15(1):83-94. | ||||
| REF 2 | cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). Biochem J. 1998 Nov 15;336 ( Pt 1):183-9. | ||||
| REF 3 | Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):536-45. | ||||
| REF 4 | Physical interaction between p53 and primary response gene Egr-1. Int J Oncol. 2001 Apr;18(4):863-70. | ||||
| REF 5 | Regulation of human microsomal prostaglandin E synthase-1 by IL-1 requires a distal enhancer element with a unique role for C/EBP. Biochem J. 2012 Apr 15;443(2):561-71. | ||||
| REF 6 | Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene. J Biol Chem. 2003 Nov 7;278(45):44246-54. | ||||
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