Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T30823 Target Info
Target Name M-phase inducer phosphatase 1 (MPIP1)
Synonyms Dual specificity phosphatase Cdc25A; Cdc25A phosphatase
Target Type Literature-reported Target
Gene Name CDC25A
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
MPIP1_HUMAN 
Target Interacting Proteins  Top
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-1 (CUL1) Interacting Protein Interacting Protein Info
UniProt ID
CUL1_HUMAN 
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
Kinases [+] 3 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [7]
Interacting Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target Interacting Protein Info
UniProt ID
CHK1_HUMAN 
Synonyms Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Chk1; Cell cycle checkpoint kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [8]
Interacting Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target Interacting Protein Info
UniProt ID
CHK2_HUMAN 
Synonyms Hucds1; hCds1; CHK2 checkpoint homolog; CHK2; Checkpoint kinase 2; Cds1 homolog; Cds1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [9]
2 Reconstituted Complex [10]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name G2/mitotic-specific cyclin B1 (CCNB1) Patented-recorded Target Interacting Protein Info
UniProt ID
CCNB1_HUMAN 
Synonyms G2/mitotic-specific cyclin-B1; Cyclin B1; CCNB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [11]
Proteins 14-3-3 [+] 3 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [12]
3 Proximity Label-MS [12]
4 Reconstituted Complex [13]
5 Yeast two hybrid [13]
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [12]
3 Proximity Label-MS [12]
Interacting Protein Name 14-3-3 protein gamma (YWHAG) Interacting Protein Interacting Protein Info
UniProt ID
1433G_HUMAN 
Synonyms 14.3.3GAMMA; PPP1R170
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [12]
3 Proximity Label-MS [12]
Other proteins [+] 3 Other proteins +
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-MS [15]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [16]
5 Affinity Capture-Western [3]
6 Affinity Capture-Western [17]
7 Affinity Capture-Western [4]
8 Affinity Capture-Western [5]
9 Reconstituted Complex [2]
10 Reconstituted Complex [4]
Interacting Protein Name F-box/WD repeat-containing protein 11 (FBXW11) Interacting Protein Interacting Protein Info
UniProt ID
FBW1B_HUMAN 
Synonyms BTRC2; BTRCP2; FBW1B; FBXW1B; Fbw11; Hos
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-MS [15]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [12]
5 Affinity Capture-Western [18]
6 Affinity Capture-Western [17]
7 Affinity Capture-Western [19]
8 Proximity Label-MS [12]
9 Reconstituted Complex [2]
10 Reconstituted Complex [4]
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [12]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Proximity Label-MS [12]
References  Top
REF 1 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 2 SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev. 2003 Dec 15;17(24):3062-74.
REF 3 Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation. Cell Cycle. 2004 Apr;3(4):469-71.
REF 4 Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature. 2003 Nov 6;426(6962):87-91.
REF 5 Regulation of lung cancer cell growth and invasiveness by beta-TRCP. Mol Carcinog. 2005 Jan;42(1):18-28.
REF 6 Dual mode of degradation of Cdc25 A phosphatase. EMBO J. 2002 Sep 16;21(18):4875-84.
REF 7 Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25. J Biol Chem. 1996 Mar 1;271(9):5118-24.
REF 8 Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 5;277(5331):1497-501.
REF 9 Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase. J Biol Chem. 2008 Jul 11;283(28):19322-8.
REF 10 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 2001 Apr 12;410(6830):842-7.
REF 11 Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell. 1991 Dec 20;67(6):1181-94.
REF 12 Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Cell Syst. 2017 Apr 26;4(4):430-444.e5.
REF 13 14-3-3 proteins associate with cdc25 phosphatases. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7892-6.
REF 14 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 15 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 16 Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene. 2010 Jun 10;29(23):3324-34.
REF 17 Identification of substrates for F-box proteins. Methods Enzymol. 2005;399:287-309.
REF 18 Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol. 2005 Apr;25(8):3338-47.
REF 19 The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-TrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis. EMBO J. 2017 Dec 15;36(24):3666-3681.

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