Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T29879 Target Info
Target Name Integrin alpha-5 (ITGA5)
Synonyms VLA-5; Integrin alpha-F; Integrin alpha-5 light chain; Integrin alpha-5 heavy chain; Fibronectin receptor subunit alpha; FNRA; CD49e antigen; CD49e; CD49 antigen-like family member E
Target Type Clinical trial Target
Gene Name ITGA5
Biochemical Class Integrin
UniProt ID
ITA5_HUMAN 
Target Interacting Proteins  Top
Integrins [+] 3 Integrins +
Interacting Target Name Integrin beta-1 (ITGB1) Clinical trial Target Interacting Protein Info
UniProt ID
ITB1_HUMAN 
Synonyms VLA-4 subunit beta; MSK12; MDF2; Integrin VLA-4 beta subunit; GPIIA; Glycoprotein IIa; FNRB; Fibronectin receptor subunit beta; Fibronectin receptor beta subunit; CD29 antigen; CD29; Beta(1) integrin
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-fractionation [3]
4 Co-fractionation [4]
Interacting Target Name Integrin alpha-4/beta-1 (ITGA4/B1) Clinical trial Target Interacting Protein Info
UniProt ID
ITA4_HUMAN-ITB1_HUMAN 
Synonyms Alpha 4 beta 1 integrin; alpha(4)beta(1) integrin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [5]
Interacting Target Name Integrin beta-3 (ITGB3) Literature-reported Target Interacting Protein Info
UniProt ID
ITB3_HUMAN 
Synonyms Platelet membrane glycoprotein IIIa; Integrin beta-3; GPIIIa; GP3A; CD61
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [3]
2 Reconstituted Complex [6]
Other proteins [+] 2 Other proteins +
Interacting Target Name Fibronectin (FN1) Clinical trial Target Interacting Protein Info
UniProt ID
FINC_HUMAN 
Synonyms Ugl-Y3; Ugl-Y2; Ugl-Y1; FN; Cold-insoluble globulin; CIG
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [8]
Interacting Target Name Angiopoietin-2 (ANGPT2) Successful Target Interacting Protein Info
UniProt ID
ANGP2_HUMAN 
Synonyms ANG-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [5]
References  Top
REF 1 Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell. 2010 Jul 20;19(1):148-59.
REF 2 SHARPIN is an endogenous inhibitor of 1-integrin activation. Nat Cell Biol. 2011 Sep 25;13(11):1315-24.
REF 3 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 4 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 5 Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with 51 integrin. J Biol Chem. 2014 Nov 7;289(45):31330-40.
REF 6 Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein. J Biol Chem. 1999 Jun 11;274(24):17257-66.
REF 7 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal. 2009 Sep 8;2(87):ra51.
REF 8 Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. J Biol Chem. 1992 Mar 25;267(9):5790-6.
REF 9 Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res. 2006 Jan 15;66(2):775-83.

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