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| Target General Information |
Top |
| Target ID |
T29754 |
Target Info
|
| Target Name |
MAPK-activated protein kinase 5 (MAPKAPK5) |
| Synonyms |
p38regulated/activated protein kinase; p38-regulated/activated protein kinase; PRAK; MK5; MK-5; MAPKactivated protein kinase 5; MAPKAPK-5; MAPKAP-K5; MAPKAP kinase 5; MAP kinaseactivated protein kinase 5; MAP kinase-activated protein kinase 5 |
| Target Type |
Discontinued Target |
| Gene Name |
MAPKAPK5 |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Heat shock proteins |
[+] 1 Heat shock proteins |
+ |
| Interacting Protein Name |
Heat shock protein beta-1 (HSPB1) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[2] |
| 3 |
Biochemical Activity |
[3] |
| 4 |
Biochemical Activity |
[1] |
| References |
Top |
| REF 1 |
PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. Cell Signal. 2009 May;21(5):712-8.
|
| REF 2 |
PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 1998 Jun 15;17(12):3372-84.
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| REF 3 |
The p38 pathway provides negative feedback for Ras proliferative signaling. J Biol Chem. 2000 Dec 15;275(50):38973-80.
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