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| Target General Information |
Top |
| Target ID |
T24714 |
Target Info
|
| Target Name |
E3 ubiquitin-protein ligase TRIP12 (TRIP12) |
| Synonyms |
ULF; Thyroid receptorinteracting protein 12; TRinteracting protein 12; TRIP12; E3 ubiquitinprotein ligase for Arf; E3 ubiquitinprotein ligase TRIP12 |
| Target Type |
Literature-reported Target |
| Gene Name |
TRIP12 |
| Biochemical Class |
Carbon-nitrogen ligase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Cell cycle related proteins |
[+] 1 Cell cycle related proteins |
+ |
| Interacting Target Name |
Multiple tumor suppressor 1 (CDKN2A) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[1] |
| Peptidases |
[+] 1 Peptidases |
+ |
| Interacting Target Name |
Herpesvirus ubiquitin-specific protease (HAUSP) |
Preclinical Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[2] |
| 2 |
Affinity Capture-Western |
[3] |
| References |
Top |
| REF 1 |
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature. 2010 Mar 25;464(7288):624-7.
|
| REF 2 |
Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
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| REF 3 |
Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response. FEBS Lett. 2016 Dec;590(23):4213-4222.
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