Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T24609 Target Info
Target Name Polypyrimidine tract-binding protein (PTBP1)
Synonyms hnRNP I; Polypyrimidine tractbinding protein 1; Polypyrimidine tract-binding protein 1; PTB; Heterogeneous nuclear ribonucleoprotein I; 57 kDa RNAbinding protein PPTB1; 57 kDa RNA-binding protein PPTB-1
Target Type Literature-reported Target
Gene Name PTBP1
UniProt ID
PTBP1_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 5 Other proteins +
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein L (HNRNPL) Interacting Protein Interacting Protein Info
UniProt ID
HNRPL_HUMAN 
Synonyms HNRPL; hnRNP.L
Evidence Score (E-score) 5 Experimental Evidences +
1 Co-fractionation [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
4 Yeast two hybrid [3]
5 Yeast two hybrid [2]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) Interacting Protein Interacting Protein Info
UniProt ID
HNRPD_HUMAN 
Synonyms AUF1; AUF1A; HNRPD; P37; hnRNPD0
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [4]
2 Co-fractionation [1]
3 Yeast two hybrid [5]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein K (HNRNPK) Interacting Protein Interacting Protein Info
UniProt ID
HNRPK_HUMAN 
Synonyms CSBP; HNRPK; TUNP
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [2]
Interacting Target Name ELAV-like protein 1 (ELAVL1) Literature-reported Target Interacting Protein Info
UniProt ID
ELAV1_HUMAN 
Synonyms HuR; Hu-antigen R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Yeast two hybrid [5]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) Interacting Protein Interacting Protein Info
UniProt ID
ROA1_HUMAN 
Synonyms Single-strand RNA-binding protein; HNRPA1; hnRNP core protein A1; hnRNP A1; Heterogeneous nuclear ribonucleoprotein A1; Helix-destabilizing protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-fractionation [4]
References  Top
REF 1 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 2 Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. J Mol Biol. 2000 May 5;298(3):395-405.
REF 3 Polypyrimidine tract-binding protein interacts with HnRNP L. FEBS Lett. 1998 Apr 3;425(3):401-6.
REF 4 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 5 Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell. 2012 Feb 24;45(4):567-80.
REF 6 RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008 Jan;28(1):93-107.
REF 7 DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature. 2012 Mar 25;484(7394):386-9.

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